neurons

[Cell Reports] In cell transplantation therapy for spinal cord injury, grafted human induced pluripotent stem cell-derived neural stem/progenitor cells (hiPSC-NS/PCs) differentiate into neurons. Scientists found that chemogenetic stimulation of hiPSC-derived neural cells enhancesd cell activity and neuron-to-neuron interactions in vitro.

[iScience] Investigators reported that irradiation with a single-frequency Terahertz laser on mice cortical neuron cultures increased excitatory synaptic transmission and neuronal firing activities.

[Scientific Reports] Researchers demonstrated that phosphatidylcholine-enriched media enhanced neuronal differentiation even under inflammatory stress by modifying the commitment of post-mitotic cells. They also provided evidence that this phospholipid ameliorated the damage of neurons and modulated neuronal plasticity.

[Neuron] Although the classic symptoms of Huntington’s disease manifest in adulthood, neural progenitor cell behavior is already abnormal by 13 weeks’ gestation. To determine how these developmental defects evolve, investigators turned to cell and mouse models.

[Molecular Therapy-Nucleic Acids] The authors provided proof of principle that allele-specific lowering of polyQ-expanded ataxin-3 by selective antisense oligonucleotides was feasible and long lasting with sparing of wildtype ataxin-3 expression in a human cell culture model that was genetically identical to spinocerebellar ataxia type 3 (SCA3) patients.

[Neuron] To investigate neurogenic potential and cellular diversity, scientists profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs.