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neurons

Quantifying Neuronal Structural Changes Over Time Using Dynamic Morphometrics

[Trends in Neurosciences] Scientists review the methods of dynamic morphometrics, consisting of detailed quantification of structural changes of neurons over time, sampling and analyses, focusing on their applications to studies of activity-driven dendritogenesis in vertebrate systems.

Neuroendocrine Cells in Prostate Cancer Correlate with Poor Outcomes: A Systematic Review and Meta-Analysis.

[BJU International] Scientists review the prognostic utility of reporting neuroendocrine staining at prostate cancer diagnosis, and determine whether different reporting approaches impact the correlation between staining and patient outcome.

Denali Therapeutics Announces Strategic Partner Takeda Exercises Option to Co-Develop and Co-Commercialize DNL593 (PTV:PGRN)

[Denali Therapeutics, Inc.] Denali Therapeutics, Inc. announced that its strategic partner Takeda Pharmaceutical Company Limited has exercised an option to co-develop and co-commercialize DNL593, an investigational, brain-penetrant progranulin replacement therapy for the potential treatment of frontotemporal dementia-granulin.

Schizophrenia Is Defined by Cell-Specific Neuropathology and Multiple Neurodevelopmental Mechanisms in Patient-Derived Cerebral Organoids

[Molecular Psychiatry] Scientists utilized patient-derived iPSCs to generate 3D cerebral organoids to model neuropathology of schizophrenia during its early-arising neurodevelopmental period.

Prilenia Receives Fast Track Designation for Pridopidine for the Treatment of Huntington’s Disease

[Prilenia Therapeutics B.V. (Business Wire, Inc.)] Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, announced that the US FDA has granted Fast Track designation to pridopidine for development as a potential treatment for Huntington’s Disease.

BH3-Only Proteins Puma and Beclin1 Regulate Autophagic Death in Neurons in Response to Amyloid-β

[Cell Death Discovery] Investigators concluded that both Beclin1 and Puma played essential roles in the neuronal death caused by the induction of aberrant autophagy in Alzheimer’s disease and that targeting their interaction could be vital to understand the crosstalk of autophagy and apoptosis.

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