neurons

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

[Frontiers in Cell and Developmental Biology] Investigators summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and discuss the opportunities and challenges associated with multifunctional skin organoids.

[Cell] Using activity-dependent cell labeling in mice, the authors captured neuronal ensembles in the InsCtx that were active under two different inflammatory conditions

[Scientific Reports] Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.

[Nature Communications] The authors identified kenpaullone (KP), which enhanced Kcc2/KCC2 expression and function in cultured rodent and human neurons by inhibiting GSK3ß. KP effectively reduced pathologic pain-like behavior in mouse models of nerve injury and bone cancer.

[Translational Psychiatry] The authors tested the chronic effects of low and high doses of lithium on human hippocampal progenitor cells and used immunocytochemistry to investigate the effects of lithium on cell parameters implicated in neurogenesis.