Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells

Using stable cell lines expressing alpha-synuclein, the authors examined the correlation between endogenous alpha-synuclein levels and the seeding propensity by exogenous alpha-synuclein preformed fibrils
[Molecular Neurobiology]
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Mechanism of miR-132-3p Promoting Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson’s Disease

Investigators collected evidence in both cell model and mouse models and showed the effect of miR-132-3p in enhancing the activation of microglial cells and the loss of microglia cells, which was achieved by mediating GLRX.
[eNeuro]
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Inactivating Celsr2 Promotes Motor Axon Fasciculation and Regeneration in Mouse and Human

Scientists showed that Celsr2 was highly expressed in both mouse and human spinal motoneurons. Celsr2 knockout promoted axon regeneration and fasciculation in mouse cultured spinal explants.
[Brain]
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Large-Scale Neural Recordings Call for New Insights to Link Brain and Behavior

Scientists describe emerging tools and technologies being used to probe large-scale brain activity and new approaches to characterize behavior in the context of such measurements.
[Nature Neuroscience]
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Neurogenic and Cognitive Enhancing Effects of Human Dental Pulp Stem Cells and its Secretome in Animal Model of Hippocampal Neurodegeneration

Probing the possible mechanisms of neuroprotection revealed that dental pulp stem cells (DPSCs)/DPSCs-conditioned media treatment upregulated an array of hosts’ endogenous neural survival factors expression.
[Brain Research Bulletin]
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Chemical Approach to Generating Long-Term Self-Renewing pMN Progenitors from Human Embryonic Stem Cells

Based on the chemical screening, the authors developed a new recipe for efficient induction of progenitors of motor neurons progenitors from human embryonic stem cells.
[Journal of Molecular Cell Biology]
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Bidirectional Cell-Matrix Interaction Dictates Neuronal Network Formation in a Brain-Mimetic 3D Scaffold

The authors bioengineered a physiologically relevant 3D scaffold by integrating brain-like extracellular matrix components and chemical cues.
[Acta Biomaterialia]
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Single-Cell Transcriptomics Captures Features of Human Midbrain Development and Dopamine Neuron Diversity in Brain Organoids

Investigators established a midbrain organoid culture system to study the developmental trajectory from pluripotent stem cells to mature dopamine neurons.
[Nature Communications]
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Cerebral Dopamine Neurotrophic Factor Protects and Repairs Dopamine Neurons by Novel Mechanism

Scientists focus on cerebral dopamine neurotrophic factor (CDNF), an unconventional neurotrophic protein. CDNF delivered to the brain parenchyma protects and restores dopamine neurons in animal models of Parkinson’s disease.
[Molecular Psychiatry]
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Novel Chemical Inhibitor against SOD1 Misfolding and Aggregation Protects Neuron-Loss and Ameliorates Disease Symptoms in ALS Mouse Model

Using ELISA-based chemical screening with wild and mutant superoxide dismutase (SOD1) proteins, the authors screened a new small molecule, PRG-A01, which could block the misfolding/aggregation of SOD1 or TDP-43. The drug rescued the cell death induced by mutant SOD1 in human neuroblastoma cell line.
[Communications Biology]
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Neurocognitive and Hypokinetic Movement Disorder with Features of Parkinsonism after BCMA-Targeting CAR-T Cell Therapy

Public transcriptomic datasets confirmed B cell maturation antigen (BCMA) RNA expression in the caudate of normal human brains, suggesting that this may be an on-target effect of anti-BCMA therapy.
[Nature Medicine]
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