neurons

[Stem Cell Research] Scientists generated human induced pluripotent stem cells from fibroblasts of a 64-year-old male patient with a homozygous ILE368ASN mutation in PINK1, who experienced disease onset at 33 years.

[Cell Reports] Employing human cerebral organoids, scientists found that chromodomain helicase DNA-binding 8 (CHD8) haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 and 120, symmetrically opposite expansions in their proportions.

[Molecular Psychiatry] Scientists combined stem cell culturing with transplantation techniques to determine disease-specific properties inherent to autism spectrum disorder astrocytes.

[Nature Communications] Scientists showed that neuroinflammation, microhemorrhages, brain hypoxia, and neuropathology that is consistent with hypoxic-ischemic injury in SARS-CoV-2 infected non-human primates, including evidence of neuron degeneration and apoptosis.

[Science Signaling] With transgenic mice that expressed a dominant-negative mutant of the pore-forming Kir6.1 subunit specifically in brain capillary endothelial cells or pericytes, scientists demonstrated that ATP-sensitive K+ channels were present in both cell types and robustly controlled membrane potential.

[Nature Neuroscience] Using single-neuron reconstruction of 6,357 mouse prefrontal cortex (PFC) projection neurons, we identified 64 projectome-defined subtypes. Each of four previously known major cortico-cortical subnetworks was targeted by a distinct group of PFC subtypes defined by their first-order axon collaterals.