Tag results:

neurons

Cortical Overgrowth in a Preclinical Forebrain Organoid Model of CNTNAP2-Associated Autism Spectrum Disorder

[Nature Communications] Investigators utilized forebrain organoids generated from induced pluripotent stem cells of patients with a syndromic form of Autism Spectrum Disorder with a homozygous protein-truncating mutation in CNTNAP2, to study its effects on embryonic cortical development.

Microglia-Neuron Interaction at Nodes of Ranvier Depends on Neuronal Activity through Potassium Release and Contributes to Remyelination

[Nature Communications] Researchers identified nodes of Ranvier as a direct site of interaction between microglia and axons, in both mouse and human tissues. Using dynamic imaging, they highlight the preferential interaction of microglial processes with nodes of Ranvier along myelinated fibers.

N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

[Scientific Reports] Investigators established an in vitro cellular model using neurons differentiated from Down syndrome (DS) patient-derived iPSCs and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more amyloid β compared to those differentiated from the euploid iPSCs.

Increased Expression of Fragmented tRNA Promoted Neuronal Necrosis

[Cell Death & Disease] Through a genome-wide small RNA sequencing, researchers identified several tRNA-derived fragments and piwi-interacting RNA species were enriched in glutamate-induced neuronal necrosis in rat primary neuron cultures, and this enrichment was dependent on the H3K4me3 increase.

N-Acetylcysteine Prevents Amyloid-β Secretion in Neurons Derived from Human Pluripotent Stem Cells with Trisomy 21

[Scientific Reports] Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs.

Differences in Synaptic Vesicle Pool Behavior between Male and Female Hippocampal Cultured Neurons

[Scientific Reports] Researchers studied functional parameters of synaptic vesicle recycling in hippocampal cultures from male and female rats, which were a standard model system for many laboratories.

Popular