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neurons

Interactions among Diameter, Myelination, and the Na/K Pump Affect Axonal Resilience to High-Frequency Spiking

[Proceedings of the National Academy of Sciences of the United States of America] Researchers found that slowing the activation of K+ current can increase the Na+ influx rate, and the effect of minimizing the overlapped between Na+ and K+ currents on spike propagation resilience depended on complex interactions among diameter, myelination, and the Na/K pump density.

Astrocyte-Neuron Metabolic Cooperation Shapes Brain Activity

[Cell Metabolism] The paradigm of this biological feature is the astrocyte-neuron couple, in which the glycolytic metabolism of astrocytes contrasts with the mitochondrial oxidative activity of neurons.

NGN2 Induces Diverse Neuron Types from Human Pluripotency

[Stem Cell Reports] Investigators used single-cell transcriptomics to dissect the cell states that emerge during NGN2 overexpression across a time course from pluripotency to neuron functional maturation.

CREB Signaling Activity Correlates with Differentiation and Survival in Medulloblastoma

[Scientific Reports] Scientists observed that during normal cerebellar development, phosphorylated CREB was selectively expressed in differentiating cerebellar granule neuron progenitor (CGNP) cells.

NGN2 Induces Diverse Neuron Types from Human Pluripotency

[Stem Cell Reports] Investigators used single-cell transcriptomics to dissect the cell states that emerge during NGN2 overexpression across a time course from pluripotency to neuron functional maturation.

Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

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