neurons

[Molecular Psychiatry] Induced pluripotent stem cells derived from individuals deficient in CDKL5 protein were used to generate neural cells. Proteomic and phosphoproteomic approaches revealed disruption of several pathways, including microtubule-based processes and cytoskeleton organization.

[Scientific Reports] Scientists used a well-established rat model to expose mother dams to alcohol, nicotine-alcohol, and saline perinatally. Dopamine (DA) and non-DA neurons collected from the ventral tegmental area (VTA) of the rat pups were used to study expression profiles of miRNAs and mRNAs.

[Science] The authors reasoned that the expansion of new neuronal types occurred in a stepwise manner analogous to animal speciation, and they explored this by defining transcriptomic relationships using a top-down approach.

[Cell] Scientists investigate the role of chaperone-mediated autophagy, a selective autophagy shown to degrade neurodegeneration-related proteins, in neuronal proteostasis.

[Stem Cell Reports] The authors assessed the importance of sequestosome-1 (SQSTM1/p62) in human induced pluripotent stem cell-derived cortical neurons through the knockout of SQSTM1.

[Developmental Cell] The authors performed single-cell transcriptomics to define embryonic hypothalamic microglia heterogeneity and identified four microglial subsets, including a subpopulation adjacent to neural stem cells that was responsive to gestational cold stress.