neurons

[Molecular Psychiatry] Investigators utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.

[Experimental & Molecular Medicine] The authors discuss the regulation of appetite and metabolism by hypothalamic neurohormone-expressing cells, with a focus on the distinct contributions of neurohormones and neurotransmitters released by these neurons.

[Science Advances] Investigators showed that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that αSyn activated the NLRP3 inflammasome in human induced pluripotent stem cell (hiPSC)-derived microglia via dual stimulation involving Toll-like receptor 2 engagement and mitochondrial damage.

[Stem Cell Reports] The authors report a novel approach that produces, within ten days, the differentiation of human induced pluripotent stem cells into microglia by forced expression of both SPI1 and CEBPA.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators developed a mouse glabrous skin behavioral assay to investigate the contribution of three previously identified pruriceptive neurons in glabrous skin itch.