neutrophils

[Nature Medicine] Using single-cell RNA sequencing and plasma proteomics, scientists discovered that, compared to bacterial acute respiratory distress syndrom, COVID-19 was associated with the expansion of distinct neutrophil states characterized by interferon and prostaglandin signaling.

[Modern Pathology] Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.

[Nature Communications] Researchers indicated that relapse can originate from therapy-resistant mature acute myeloid leukemia cells, and suggested differentiation therapy combined with targeted eradication of mature leukemia-derived lineages may improve disease outcome.

[Journal of Physiology] Researchers defined the nature of microvascular damage and time course of repair during muscle injury and regeneration induced by the myotoxin BaCl2.

[Scientific Reports] Investigators found that elastolysis of elastic fibers and collagen accumulation contributed to vascular stiffening and arterial hypertension. Therefore, apelin expression could be a major element to preserve vascular homeostasis.

[Cell Death Discovery] Investigators isolated radiation-induced senescent tdTOMp16 positive MSCs, established their absence of cell division, then measured levels of irradiation-induced expression of biomarkers of senescence by RNA-seq analysis.