neutrophils

[Molecular Therapy] Pulmonary viral burden was reduced by anti-SARS-CoV-2 antibody treatment, and similar or increased by dexamethasone alone. Dexamethasone exhibited strong anti-inflammatory effects and prevented fulminant disease in a severe disease model.

[Immunology & Cell Biology] Researchers presented a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection.

[Proceedings of the National Academy of Sciences of the United States of America] 12,13-dihydroxyoctadecenoic acid was found to facilitate the maturation and activation of stimulated neutrophils, while impeding monocyte and macrophage functionality and cytokine generation.

[Clinical Cancer Research] Tumor and blood samples were analyzed by flow cytometry, immunohistochemistry, transcriptome and cytokine profiling. Cabozantinib-related effects were validated in a colorectal cancer PDX model.

[Cell Stem Cell] Scientists showed that loss of nuclear lamin B1 (LMNB1) encoded on chromosome 5q, which was frequently deleted in myeloid neoplasms, induced defects in nuclear morphology and human HSCs function associated with malignancy.

[Science Signaling] In human pulmonary aortic endothelial cells,lipopolysaccharide (LPS) induced decreased in the amounts of endothelial nitric oxide synthase, thrombomodulin, and vascular endothelial–cadherin, which was blocked by treatment with UNC2250.