neutrophils

[European Respiratory Journal] The authors used a mouse model of concurrent cigarette smoke exposure and H1N1 influenza infection, colony-stimulating factor (CSF)3 supplementation/receptor blockade, and single-cell RNA sequencing to investigate this relationship.

[American Journal of Respiratory and Critical Care Medicine] The healthy human neutrophil secretome generated under normoxic or hypoxic conditions was characterized by quantitative mass spectrometry, and the capacity for neutrophil-mediated endothelial damage assessed.

[FEBS Journal] Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.

[Journal of Leukocyte Biology] Scientists present an overview of neutrophil heterogeneity and its impact on the course and severity of viral respiratory infectious diseases.

[Cellular & Molecular Immunology] The authors highlight the interaction of neutrophils with other cells in the context of chronic inflammation, the contribution of neutrophils to selected chronic inflammatory diseases, and possible future therapeutic strategies.

[Nature Reviews Gastroenterology & Hepatology] The authors outline the evidence in support of neutrophils as drivers of hepatocellular carcinoma and detail their mechanistic roles in development, progression and metastasis, highlighting the reasons that neutrophils are well worth investigating despite the challenges associated with studying them.