NF-κB

[BMC Cancer] A higher matrix stiffness equipped tumor cells with enhanced stemness and proliferative characteristics, which was dependent on the activation of integrin β1/FAK/ERK1/2/NF-κB signaling pathway.

[Molecular Cancer Research] Investigators showed that an unanticipated severe tumor phenotype was contributed collectively by severe cholestasis, metabolic changes, upregulated cell cycle progression and disruption of circadian rhythm in mutant hepatocytes.

[Cell Metabolism] Using single-cell transcriptomics, the authors identified a small, critically important, but previously unexamined cell population, p21Cip1 highly expressing (p21high) cells, which accumulated in adipose tissue with obesity.

[Nature Cancer] Scientists found that small extracellular vesicles derived from metastatic melanoma cell lines were enriched in nerve growth factor receptor, spread through the lymphatic system and were taken up by lymphatic endothelial cells, reinforcing lymph node metastasis.

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that vitexin, a natural flavonoid, could inhibit the activation of apurinic/apyrimidinic endonuclease1 (APEX1) to protect vascular endothelium against the adverse effects of atherogenic stimuli.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.