obesity

[Obesity Reviews] Scientists present recent studies that support an important role for endothelial cells as central mediators of many of the physiological and pathological functions of the adipose tissue and highlight several unknown aspects of adipose tissue vascular biology.

[Cellular & Molecular Immunology] Investigators review the key findings that have shaped our understanding of how immune cells regulate adipose tissue homeostasis to control organismal metabolism.

[Nature Communications] Researchers reported that the food amount was a positive determinant of the gut surface area contributing to an increased absorptive function, reversible by reducing daily food.

[Nature Communications] Investigators showed GP73, a Golgi protein upregulated in livers from patients with a variety of liver diseases, exhibits Rab GTPase-activating protein activity regulating ApoB export.

[Signal Transduction and Targeted Therapy] The authors showed that natural killer (NK)-derived exosomes from lean mice attenuated obesity-induced insulin resistance and inflammation in mice of type 2 diabetes, and that lean NK-derived exosomes enhanced insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.

[Oncogenesis] Elevated ATGL levels in human colon cancer cells relative to non-transformed were augmented by an obesity mediator, oleic acid.