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obesity

Hyperleptinemia in Obese State Renders Luminal Breast Cancers Refractory to Tamoxifen by Coordinating a Crosstalk between Med1, miR205 and ErbB

[npj Breast Cancer] Exogenous leptin abrogated tamoxifen-mediated growth inhibition and potentiated breast tumor growth even in the presence of tamoxifen.

Inflammasome Activation at the Crux of Severe COVID-19

[Nature Reviews Immunology] Scientists review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, leading to secretion of the pleiotropic IL-1 family cytokines and pyroptosis.

ITLN1 Inhibits Tumor Neovascularization and Myeloid Derived Suppressor Cells Accumulation in Colorectal Carcinoma

[Oncogene] Researchers explored the inhibitory role of ITLN1 in the tumor-permissive microenvironment that existed during the first occurrence and subsequent development of colorectal carcinoma.

IL-25–Induced Shifts in Macrophage Polarization Promote Development of Beige Fat and Improve Metabolic Homeostasis in Mice

[PLoS Biology] Scientists found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B, increased in adipose tissue after cold exposure and β3-adrenoceptor agonist stimulation.

Maternal Immune Activation and Neuroinflammation in Human Neurodevelopmental Disorders

[Nature Reviews Neurology] The authors focus on the emerging human evidence for an association between maternal immune activation and childhood neurodevelopmental disorders, including autism spectrum disorder, attention-deficit/hyperactivity disorder and Tourette syndrome.

Effect of Adipose Derived Mesenchymal Stem Cells on Multiple Organ Injuries in Diet-Induced Obese Mice

[Tissue Barriers] Scientists studied the effect of adipose-derived MSCs on obesity-induced multi-organ injuries in a diet-induced obese mouse model.

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