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obesity

Post-Acute Sequelae of COVID-19: A Metabolic Perspective

[eLife] The authors explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and post-acute sequelae of CoV-2, and then consider how these might be targeted for future therapeutic approaches.

Human Umbilical Cord-Derived Mesenchymal Stem Cells Alleviate Insulin Resistance in Diet-Induced Obese Mice via an Interaction with Splenocytes

[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.

Autophagy Impairment in Liver CD11c+ Cells Promotes Non-alcoholic Fatty Liver Disease through Production of IL-23

[Nature Communications] Scientists explored the effect of Autophagy-related 5 (Atg5) deficiency in liver CD11c+ cells in mice fed HFD. When compared to control mice, Atg5-deficient CD11c+ mice exhibit increased glucose intolerance and decreased insulin sensitivity when fed HFD.

Autophagy Impairment in Liver CD11c+ Cells Promotes Non-Alcoholic Fatty Liver Disease through Production of IL-23

[Nature Communications] The authors demonstrated that both therapeutic and preventative IL-23 blockade alleviated glucose intolerance, insulin resistance and protects against non-alcoholic fatty liver diseasedevelopment.

Cancer-Inducing Niche: The Force of Chronic Inflammation

[British Journal of Cancer] The authors suggest that chronic diseases, including obesity and diabetes, establish the cancer-inducing niche that drives the undifferentiated/progenitor cells into CSCs, which then develop malignant tumours in vivo.

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus

[Current Diabetes Reports] Investigators focus on the recent development of new clinically validated and novel biomarkers as well as the methods that represent cost-effective alternatives for screening and early diagnosis of type 2 diabetes mellitus.

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