obesity

[Acta Pharmacologica Sinica] Scientists investigated the protective effect of Dapa against cardiomyopathy caused by high fat diet-induced obesity in vitro and in vivo.

[Journal of Mammary Gland Biology and Neoplasia] Investigators found that chronic leptin treatment induced a switch from an epithelial to a mesenchymal morphology, partial loss of E-cadherin and gain of vimentin expression.

[Lancet Diabetes & Endocrinology] Investigators discuss how diabetes can affect the development of hepatic steatosis and its progression to advanced liver damage.

[Nature Metabolism] The authors showed that membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) was an endogenous negative regulator of GDNF-family receptor a-like (GFRAL) in the context of obesity.

[Journal of Clinical Endocrinology & Metabolism] Investigators focus on the potential role of growth hormone and insulin-like growth factor I in the regulation of hepatic steatosis, inflammation, and fibrosis.

[Haematologica] Researchers studied the influence of anthropometric and body composition measurements on CAR-T-related immunotoxicity in 64 patients receiving CD19-directed CAR-T for relapsed/refractory B cell malignancies.