obesity

[Nature Communications] Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.

[Blood Cancer Discovery] Researchers analyzed the expression profile of adipose tissue-derived stem cells co-cultured with cervical cancer cells through massive RNA sequencing followed by evaluation of various functional alterations resulting from the modified transcriptome.

[Obesity Reviews] Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.

[Prostate Cancer and Prostatic Diseases] The association of obesity with biochemical recurrence (BCR) after treatment of clinically localized prostate cancer shows inconsistent results. Scientists systematically review all evidence evaluating obesity as a prognostic factor for BCR.

[Cell Reports] Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.

[Molecular Therapy-Nucleic Acids] Scientists found that decreased function of fat mass and obesity-associated protein (FTO) expression in clinical specimens correlated with higher glioma grades and poorer clinical outcomes. Functionally, FTO inhibited growth and invasion in glioblatoma cells in vitro and in vivo.