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organoids

Spontaneous Activity of the Mitochondrial Apoptosis Pathway Drives Chromosomal Defects, the Appearance of Micronuclei and Cancer Metastasis through the Caspase-Activated DNAse

[Cell Death & Disease] Inhibition of mitochondrial apoptosis or of Caspase-activated DNAse reduced the number of micronuclei in tumor cell lines as well as the number of chromosomal misalignments in tumor cells and intestinal organoids.

Fukushima Medical University Aim to Accelerate Cancer Research by Contributing Their Patient Derived Organoids to the CancerTools.org Initiative

[Fukushima Medical University (MarketScreener)] CancerTools.org, the research tools arm of Cancer Research UK, and the Fukushima Medical University and Summit Pharmaceuticals International announced a new partnership to progress their shared mission of accelerating cancer research. Through this partnership, FMU will maketheir patient derived organoids available to the global cancer research tools community.

Plumbing Our Organs: Lessons from Vascular Development to Instruct Lab Generated Tissues

[Current Topics in Developmental Biology] Scientists review what's been learned from embryonic blood vessels and how this knowledge instructs our approaches to vascularize laboratory generated tissues, such as organoids.

Secreted NF-κB Suppressive Microbial Metabolites Modulate Gut Inflammation

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

Secreted NF-κB Suppressive Microbial Metabolites Modulate Gut Inflammation

[Cell Reports] Researchers identified five Clostridium strains that suppressed immune-mediated NF-κB activation in epithelial cell lines, peripheral blood mononuclear cells, and gut epithelial organoids from healthy human subjects and patients with inflammatory bowel disease.

Pancreatic Ductal Adenocarcinoma Cells Employ Integrin α6β4 to Form Hemidesmosomes and Regulate Cell Proliferation

[Matrix Biology] To identify the integrin adhesion systems that operate in PDAC, investigators analyzed a range of pancreatic ductal epithelial cell models using 2D, 3D and organoid culture systems.

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