An in vitro model using human colon organoids was established by 60 weeks of inflammatory stimulation. The key gene for mucosal injury caused by long-term inflammation was identified by microarray analysis. An in vivo model was established by xenotransplantation of organoids into mouse colonic mucosa.
[Journal of Crohns & Colitis]
Watanabe, S., Nishimura, R., Shirasaki, T., Katsukura, N., Hibiya, S., Kirimura, S., Negi, M., Okamoto, R., Matsumoto, Y., Nakamura, T., Watanabe, M., & Tsuchiya, K. (2021). Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis. Journal of Crohn’s and Colitis, jjab032. https://doi.org/10.1093/ecco-jcc/jjab032 Cite
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