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organoids

Cold Atmospheric Plasma Differentially Affects Cell Renewal and Differentiation of Stem Cells and APC-Deficient-Derived Tumor Cells in Intestinal Organoids

[Cell Death Discovery] Scientists addressed the relevance of three-dimensional organoid technology to investigate the biological effects of cold atmospheric plasma on normal epithelial stem cells and tumor cells isolated from mouse small intestine.

Suspension Culture Promotes Serosal Mesothelial Development in Human Intestinal Organoids

[Cell Reports] Researchers described suspension culture as a simple, low-maintenance method for culturing human intestinal organoids and for promoting in vitro differentiation of an organized serosal mesothelial layer that was similar to primary human intestinal serosal mesothelium based on single-cell RNA sequencing and histological analysis.

Human Pancreatic Tumour Organoid-Derived Factors Enhance Myogenic Differentiation

[Journal of Cachexia Sarcopenia and Muscle] Scientists investigated the effect of pancreatic tumour organoid-derived factors on processes that determine skeletal muscle mass, including the regulation of muscle protein turnover and myogenesis.

Assessing GQ-GPCR–Induced Human Astrocyte Reactivity Using Bioengineered Neural Organoids

[Journal of Cell Biology] Scientists devised a straightforward bioengineered neural organoid culture approach entailing transcription factor–driven direct differentiation of neurons and astrocytes from human PSC combined with genetically encoded tools for dual cell-selective activation.

Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea

[Science Advances] Researchers showed that LIN28B and follistatin coactivation enhanced spontaneous cochlear hair cell (HC) regeneration in neonatal mice and that LIN28B may be part of an endogenous repair mechanism that primed support cells for HC regeneration.

Human Embryoid Bodies as a Novel System for Genomic Studies of Functionally Diverse Cell Types

[eLife] The authors generated embryoid bodies (EBs) from induced pluripotent stem cells (iPSCs) using a strong mixed-pool study design and performed scRNA-seq profiling.

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