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organoids

Generation of the Organotypic Kidney Structure by Integrating Pluripotent Stem Cell-Derived Renal Stroma

[Nature Communications] By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, researchers herein established an in vitro induction protocol for stromal progenitors from mouse PSCs.

Cone Photoreceptors in Human Stem Cell-Derived Retinal Organoids Demonstrate Intrinsic Light Responses That Mimic Those of Primate Fovea

[Cell Stem Cell] Investigators showed strong, graded, repetitive, and wavelength-specific light-evoked responses from retinal organoid cones.

Attenuation of SARS-CoV-2 Infection by Losartan in Human Kidney Organoids

[iScience] Using iPSC derived-kidney organoids, SARS-CoV-1, SARS-CoV-2 and MERS-CoV tropism, defined by the paired expression of a host receptor and protease, was identified primarily amongst proximal tubule cells.

IL-17RA-Signaling in Lgr5+ Intestinal Stem Cells Induces Expression of Transcription Factor ATOH1 to Promote Secretory Cell Lineage Commitment

[Immunity] The authors used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut.

Amplification of Human Interneuron Progenitors Promotes Brain Tumors and Neurological Defects

[Science] Investigators generated a human model for tuberous sclerosis complex (TSC) by growing cerebral organoids from patients who carried mutations in TSC2.

Efficient and Error-Free Fluorescent Gene Tagging in Human Organoids without Double-Strand DNA Cleavage

[PLoS Biology] Scientists showed that in-trans paired nicking allowed for fast, highly efficient, and indel-free fluorescent gene tagging in human normal and cancer organoids.

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