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organoids

Recapitulating Lipid Accumulation and Related Metabolic Dysregulation in Human Liver-Derived Organoids

[Journal of Molecular Medicine] Scientists developed an organoid-based 3D culture model to recapitulate key features of fatty liver disease focusing on intracellular lipid accumulation and metabolic dysregulation.

Biomimetic Models of the Glomerulus

[Nature Reviews Nephrology] Scaffold-based 3D culture systems and organoids provide greater microenvironmental complexity but do not replicate fluid flows and dynamic responses to fluidic stimuli.

Single-Cell ATAC-Seq of Fetal Human Retina and Stem-Cell-Derived Retinal Organoids Shows Changing Chromatin Landscapes during Cell Fate Acquisition

[Cell Reports] Researchers extended the transcriptomic analyses to incorporate single-cell assay for transposase-accessible chromatin sequencing, a powerful method used to characterize potential gene regulatory networks through the changes in accessible chromatin that accompany cell-state changes.

Fasting Improves Therapeutic Response in Hepatocellular Carcinoma through p53-Dependent Metabolic Synergism

[Science Advances] Scientists showed in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improved sorafenib efficacy and acted synergistically to sensitize sorafenib-resistant HCC.

SARS-CoV-2 Infection Triggers Paracrine Senescence and Leads to a Sustained Senescence-Associated Inflammatory Response

[Nature Aging] In cultured human cells or bronchial organoids, SASR-CoV-2 infection-induced senescent cells expressed high levels of a series of inflammatory factors known as senescence-associated secretory phenotypes 4 in a sustained manner, even after SARS-CoV-2 was no longer detectable.

Canonical TGFβ Signaling Induces Collective Invasion in Colorectal Carcinogenesis through a Snail1- and Zeb1-Independent Partial EMT

[Oncogene] The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.

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