Tag results:
organoids
Neural Cell News
Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-Associated Gene Expression
[American Journal of Human Genetics] The authors compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain.
Neural Cell News
Reaching into the Toolbox: Stem Cell Models to Study Neuropsychiatric Disorders
[Stem Cell Reports] Investigators discussed available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based 2D models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.
Neural Cell News
Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids
[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.
Hepatic Cell News
Recapitulating Hepatitis E Virus–Host Interactions and Facilitating Antiviral Drug Discovery in Human Liver–Derived Organoids
[Science Advances] Scientists demonstrated that 3D cultured organoids from fetal and adult human liver with cholangiocyte or hepatocyte phenotype supported hepatitis E virus replication.
Intestinal Cell News
Anti-miR-135/SPOCK1 Axis Antagonizes the Influence of Metabolism on Drug Response in Intestinal/Colon Tumor Organoids
[Oncogenesis] The authors analyzed the expression of 373 miRNAs and 12 deregulated metabolic genes in murine duodenal polyps and non-polyp-derived organoids.
Hepatic Cell News
RNF43/ZNRF3 Loss Predisposes to Hepatocellular-Carcinoma by Impairing Liver Regeneration and Altering the Liver Lipid Metabolic Ground-State
[Nature Communications] Using hepatocyte-, hepatoblast- and ductal cell-derived organoids, investigators demonstrated that the differentiation defects and lipid alterations were, in part, cell-autonomous.