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organoids

Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-Associated Gene Expression

[American Journal of Human Genetics] The authors compared single-cell RNA-sequencing data of human midbrain organoids to the developing human embryonic midbrain.

Reaching into the Toolbox: Stem Cell Models to Study Neuropsychiatric Disorders

[Stem Cell Reports] Investigators discussed available tools, including CRISPR-Cas9, and the applications of these tools to develop cell-based 2D models and 3D brain organoid models that better represent and unravel the intricacies of neuropsychiatric disorder pathophysiology.

Expression of the Transcription Factor PU.1 Induces the Generation of Microglia-Like Cells in Human Cortical Organoids

[Nature Communications] The authors developed a method to generate functional microglia in human cortical organoids from human embryonic stem cells.

Recapitulating Hepatitis E Virus–Host Interactions and Facilitating Antiviral Drug Discovery in Human Liver–Derived Organoids

[Science Advances] Scientists demonstrated that 3D cultured organoids from fetal and adult human liver with cholangiocyte or hepatocyte phenotype supported hepatitis E virus replication.

Anti-miR-135/SPOCK1 Axis Antagonizes the Influence of Metabolism on Drug Response in Intestinal/Colon Tumor Organoids

[Oncogenesis] The authors analyzed the expression of 373 miRNAs and 12 deregulated metabolic genes in murine duodenal polyps and non-polyp-derived organoids.

RNF43/ZNRF3 Loss Predisposes to Hepatocellular-Carcinoma by Impairing Liver Regeneration and Altering the Liver Lipid Metabolic Ground-State

[Nature Communications] Using hepatocyte-, hepatoblast- and ductal cell-derived organoids, investigators demonstrated that the differentiation defects and lipid alterations were, in part, cell-autonomous.

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