organoids

[Cell Stem Cell] The authors highlight the recent remarkable progress on multicellular cardiac organoids and review the current status for their practical applications.

[Nature Communications] Investigators showed that the aryl hydrocarbon receptor was important for the termination of the regenerative response and the reacquisition of mature epithelial cell identity post injury in vivo and in organoid cultures in vitro.

[Stem Cell Reports] Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.

[Cell Reports] Researchers defined mesenchymal and stem-like prostate cancer, traced its origin to therapy-induced lineage plasticity, and revealed its sensitivity to HER2/3 inhibition.

[Nature Methods] Scientists overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development.

[Helicobacter] The authors discuss the advantages and limitations of existing in vivo and in vitro models of Helicobacter pylori (H. pylori) infection, and how gastric organoids have been applied to study H. pylori pathogenesis.