Single-Cell Analysis of Human Primary Prostate Cancer Reveals the Heterogeneity of Tumor-Associated Epithelial Cell States

Researchers uncovered heterogeneous cellular states in prostate epithelial cells marked by high androgen signaling states that were enriched in prostate cancer and identified a population of tumor-associated club cells that may be associated with prostate carcinogenesis.
[Nature Communications]
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Evaluating Initial Integration of Cell-Based Chondrogenic Constructs in Human Osteochondral Explants

Investigators examined whether integration of allogeneic cell-based implants with the surrounding native cartilage could be demonstrated in an ex vivo human osteochondral culture model.
[Tissue Engineering Part C-Methods]
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Integrated Stem Cells from Apical Papilla in a 3D Culture System Improve Human Embryonic Stem Cell Derived Retinal Organoid Formation

The authors assessed the effective interactions of mesenchymal stem cells and human embryonic stem cells during retinal organoid formation.
[Life Sciences]
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The Ubiquitin-Dependent ATPase p97 Removes Cytotoxic Trapped PARP1 from Chromatin

Using wild-type and a trapping-deficient poly (ADP-ribose) polymerase (PARP1) mutant combined with rapid immunoprecipitation mass spectrometry of endogenous proteins and Apex2 proximity labeling, investigators delineated mass spectrometry-based interactomes of trapped and non-trapped PARP1.
[Nature Cell Biology]
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High-Throughput Formation and Image-Based Analysis of Basal-In Mammary Organoids in 384-Well Plates

This analysis protocol utilized morphological image processing to identify cellular structures within each image and quantify their circularity and size. Using this script, time-lapse images of aggregating and non-aggregating culture conditions are analyzed to profile early changes in size and circularity.
[Scientific Reports]
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Establishment of Gastric Signet Ring Cell Carcinoma Organoid for the Therapeutic Drug Testing

Scientists reported gastric organoids established from tumor tissues comprising four signet ring cell carcinoma (SRCCs) and eight non-SRCCs.
[Cell Death Discovery]
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Controlling Morphology and Functions of Cardiac Organoids by Two-Dimensional Geometrical Templates

Investigators developed a new method to generate 3D spatial-organized cardiac organoids from 2D micropatterned hiPSC colonies, instead of directly from 3D stem cell aggregates.
[Cell Tissues Organs]
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When Stem Cells Meet COVID-19: Recent Advances, Challenges and Future Perspectives

Investigators discuss how stem cells play a role in the battle against COVID-19 and present a systematic review and prospective of the study on stem cell treatment and organoid models of COVID-19, which provides a reference for the effective control of the COVID-19 pandemic worldwide.
[Stem Cell Research & Therapy]
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Prellis Biologics Announces Collaboration and License Agreement with Bristol Myers Squibb

Prellis Biologics, Inc. announced that it has entered into a multi-target drug discovery collaboration and licensing agreement with Bristol Myers Squibb utilizing Prellis Biologics’ first-in-class externalized human immune system based on human lymph node organoids.
[Prellis Biologics, Inc. (Business Wire, Inc.)]
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Stretchable Mesh Nanoelectronics for Three-Dimensional Single-Cell Chronic Electrophysiology from Developing Brain Organoids

The authors reported a cyborg brain organoid platform, in which “tissue-like” stretchable mesh nanoelectronics are designed to match the mechanical properties of brain organoids and to be folded by the organogenetic process of progenitor or stem cells, distributing stretchable electrode arrays across the 3D organoids.
[Advanced Materials]
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FASN-Dependent De Novo Lipogenesis Is Required for Brain Development

Scientists established a role of de novo lipogenesis for mouse and human brain development and identified a link between progenitor-cell polarity and lipid metabolism.
[Proceedings of the National Academy of Sciences of the United States of America]
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