5-Hydroxymethylcytosine Is Dynamically Regulated during Forebrain Organoid Development and Aberrantly Altered in Alzheimer’s Disease

Scientists generated 5-hydroxymethylcytosine and transcriptome profiles encompassing several developmental time points of healthy forebrain organoids and organoids derived from several familial Alzheimer’s disease patients.
[Cell Reports]
Kuehner, J. N., Chen, J., Bruggeman, E. C., Wang, F., Li, Y., Xu, C., McEachin, Z. T., Li, Z., Chen, L., Hales, C. M., Wen, Z., Yang, J., & Yao, B. (2021). 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer’s disease. Cell Reports, 35(4). https://doi.org/10.1016/j.celrep.2021.109042 Cite
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Translating Complexity and Heterogeneity of Pancreatic tumor: 3D In Vitro to In Vivo Models

The authors provide an overview of the recent developments in different in vitro and in vivo models, which aim to recapitulate the complexity of pancreatic ductal adenocarcinoma in a laboratory environment, as well to describe how 3D in vitro models can be included into drug development pipelines that are already including sophisticated in vivo models.
[Advanced Drug Delivery Reviews]
Translating Complexity and Heterogeneity of Pancreatic tumor: 3D In Vitro to In Vivo Models. (2021). Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2021.04.018 Cite
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Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine

New models of posterior embryo development identify neuromesodermal progenitors as a major bifurcation point in generating the spinal cord and somites and is leading to production of cell types with the full range of axial identities critical for repair of trunk and spine disorders. This is coupled with organoid technologies including assembloids, circuitoids, and gastruloids.
[Frontiers in Cellular Neuroscience]
Olmsted, Z. T., & Paluh, J. L. (2021). Stem Cell Neurodevelopmental Solutions for Restorative Treatments of the Human Trunk and Spine. Frontiers in Cellular Neuroscience, 15. https://doi.org/10.3389/fncel.2021.667590 Cite
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Prostaglandin F2α Agonists Induced Enhancement in Collagen1 Expression Is Involved in the Pathogenesis of the Deepening of Upper Eyelid Sulcus

The effects of prostaglandin F2α analogues (PGF2α-ags) on human orbital fibroblasts were characterized by lipid staining, comparison of the 3D organoid sizes of preadipocytes or adipocytes that had been treated with various concentrations of several PGF2α-ags, physical stiffness, and the mRNA expression of adipogenic related genes, extracellular matrix, tissue inhibitors of metalloproteinases and matrix metalloproteinases.
[Scientific Reports]
Itoh, K., Ida, Y., Ohguro, H., & Hikage, F. (2021). Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus. Scientific Reports, 11(1), 9002. https://doi.org/10.1038/s41598-021-88562-4 Cite
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Applications of Brain Organoids in Neurodevelopment and Neurological Diseases

Scientists introduce the current state of brain organoid differentiation strategies, summarize current progress and applications in the medical domain, and discuss the challenges and prospects of this promising technology.
[Journal of Biomedical Science]
Sun, N., Meng, X., Liu, Y., Song, D., Jiang, C., & Cai, J. (2021). Applications of brain organoids in neurodevelopment and neurological diseases. Journal of Biomedical Science, 28(1), 30. https://doi.org/10.1186/s12929-021-00728-4 Cite
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Fetal Lung Underdevelopment Is Rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles in Rodents

The authors describe a stem cell-based approach in rodents that enhanced fetal lung development via the administration of extracellular vesicles derived from amniotic fluid stem cells
[Science Translational Medicine]
Antounians, L., Catania, V. D., Montalva, L., Liu, B. D., Hou, H., Chan, C., Matei, A. C., Tzanetakis, A., Li, B., Figueira, R. L., Costa, K. M. da, Wong, A. P., Mitchell, R., David, A. L., Patel, K., Coppi, P. D., Sbragia, L., Wilson, M. D., Rossant, J., & Zani, A. (2021). Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents. Science Translational Medicine, 13(590). https://doi.org/10.1126/scitranslmed.aax5941 Cite
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Establishment of Functional Epithelial Organoids from Human Lacrimal Glands

Researchers demonstrated that the established lacrimal gland (LG) organoids resembled the characteristics of normal LG tissue and may be used as a therapy for patients with dry eye disease.
[Stem Cell Research & Therapy]
Jeong, S. Y., Choi, W. H., Jeon, S. G., Lee, S., Park, J.-M., Park, M., Lee, H., Lew, H., & Yoo, J. (2021). Establishment of functional epithelial organoids from human lacrimal glands. Stem Cell Research & Therapy, 12(1), 247. https://doi.org/10.1186/s13287-021-02133-y Cite
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Engineering Spatial-Organized Cardiac Organoids for Developmental Toxicity Testing

The authors investigated how geometric confinement directed the structural morphology and contractile functions of the cardiac organoids and tailored the pattern geometry to optimize organoid production.
[Stem Cell Reports]
Hoang, P., Kowalczewski, A., Sun, S., Winston, T. S., Archilla, A. M., Lemus, S. M., Ercan-Sencicek, A. G., Gupta, A. R., Liu, W., Kontaridis, M. I., Amack, J. D., & Ma, Z. (2021). Engineering spatial-organized cardiac organoids for developmental toxicity testing. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.013 Cite
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Engineering Hydrogels for Personalized Disease Modeling and Regenerative Medicine

Scientists review recent progress in the use of hydrogels to create artificial cellular microenvironments for personalized tissue engineering and regenerative medicine applications, as well as to develop personalized disease models.
[Acta Biomaterialia]
Tayler, I. M., & Stowers, R. S. (2021). Engineering Hydrogels for Personalized Disease Modeling and Regenerative Medicine. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2021.04.020 Cite
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Transmission, Infectivity, and Neutralization of a Spike L452R SARS-CoV-2 Variant

Scientists identified an emerging SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California.
[Cell]
Deng, X., Garcia-Knight, M. A., Khalid, M. M., Servellita, V., Wang, C., Morris, M. K., Sotomayor-González, A., Glasner, D. R., Reyes, K. R., Gliwa, A. S., Reddy, N. P., Martin, C. S. S., Federman, S., Cheng, J., Balcerek, J., Taylor, J., Streithorst, J. A., Miller, S., Sreekumar, B., … Chiu, C. Y. (2021). Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.04.025 Cite
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RAC1B Modulates Intestinal Tumorigenesis via Modulation of WNT and EGFR Signaling Pathways

Scientists identified RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment.
[Nature Communications]
Gudiño, V., Pohl, S. Ö.-G., Billard, C. V., Cammareri, P., Bolado, A., Aitken, S., Stevenson, D., Hall, A. E., Agostino, M., Cassidy, J., Nixon, C., von Kriegsheim, A., Freile, P., Popplewell, L., Dickson, G., Murphy, L., Wheeler, A., Dunlop, M., Din, F., … Myant, K. B. (2021). RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nature Communications, 12(1), 2335. https://doi.org/10.1038/s41467-021-22531-3 Cite
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