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organoids

Tissue Geometry Drives Deterministic Organoid Patterning

[Science] Scientists developed approaches for specifying the initial organoid geometry to build intestinal organoids of defined shape, size, and cell distributions, forming structures that were predictable, more similar to normal organs, and reproducible.

Modeling Somatic Mutations Associated with Neurodevelopmental Disorders in Human Brain Organoids

[Frontiers in Molecular Neuroscience] Brain organoids capture the developmental progression of the human brain and contain human-enriched progenitor cell types.

Challenges of Organoid Research

[Annual Review of Neuroscience] Organoids hold promise for the study of atypical cellular, molecular, and genetic features that underscore neurological diseases.

ID2 Controls Differentiation of Enteroendocrine Cells in Mouse Small Intestine

[Acta Physiologica] To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.

Ionizing Radiation Alters Organoid Forming Potential and Replenishment Rate in a Dose/Dose-Rate Dependent Manner

[Journal of Radiation Research] Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.

Deletion of kif3a in CK19 Positive Cells Leads to Primary Cilia Loss, Biliary Cell Proliferation and Cystic Liver Lesions in TAA-Treated Mice

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Biliary progenitor cells were isolated and grown as organoids from gallbladders. Cells and tissue were analyzed using histology, immunohistochemistry and Western blot assays.

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