organoids

[Molecular & Cellular Proteomics] Researchers comprehensively compared three popular Matrigel dissolving methods and investigated the effect of undissolved Matrigel proteins on proteomic profiles of organoids.

[Development] By applying outer plexiform layer (OPL) staging criteria to human retinal organoids derived from human embryonic and iPSC, scientists observed comparable maturation from OPL-Stage 0 at day 100 in culture up to OPL-Stage 3 by day 160.

[European Respiratory Journal] Scientists exploited an innovative cellular approach allowing highly efficient in vitro expansion of airway epithelial stem cells through conditional reprogramming from nasal brushing of cystic fibrosis patients.

[Nucleic Acids Research] Scientists translated a newly developed pooled RNA-seq methodology onto a superhydrophobic microwell array chip to realize an assay of genome-wide RNA output unified with phenotypic data.

[Frontiers in Cell and Developmental Biology] Scientists found that halofuginone inhibited the proliferation, induced G0/G1 phase arrest, and promoted apoptosis in lung cancer cells in a dose-dependent manner.

[Journal of Molecular Biology] The advent of brain organoid technology has provided a new means to study the cause and progression of developmental brain diseases in vitro.