organoids

[PLoS Genetics] Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.

[Environmental Health Perspectives] Cell-based assays, primary organoid cultures, and PXR conditional knockout and PXR-humanized mouse models were used to investigate the impact of DCHP exposure on PXR activation and lipid homeostasis in vitro and in vivo.

[Small] Transformation of conventional 2D platforms into unusual 3D configurations provides exciting opportunities for sensors, electronics, optical devices, and biological systems.

[NextVivo (BusinessWire, Inc.)] NextVivo emerged from stealth with $7.9M in financing led by Khosla Ventures, with participation from Alexandria Venture Investments with plans to develop the first organoid platform able to generate and test therapies in immune-competent human-derived models.

[Artificial Organs] Investigators describe the decellularization and sterilization methods that are commonly used in recent research, and the effects of these methods upon biologic scaffold material.

[Scientific Reports] Scientists generated UM-002, a novel brain penetrant bromodomain and extraterminal domain (BET) inhibitor that reduced glioblastoma cell proliferation in vitro and in a human cerebral brain organoid model.