organoids

[Biosensors & Bioelectronics] Scientists reported Fourier light-field microscopy using a hybrid point-spread function for fast, volumetric, and high-resolution imaging of entire organoids.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] To explore a role for reflux-induced epithelial-mesenchymal plasticity in Barrett's esophagus, scientists established and characterized human Barrett's organoids, and sought evidence of epithelial-mesenchymal plasticity after treatment with acidic bile salts

[Toxicology Letters] Small intestinal organoids were used to assess if arsenic exposure would also impair intestinal stem cell differentiation. No changes in markers of differentiated epithelial cells were seen.

[Open Biology] Investigators discuss the role of epigenetic and metabolic dysregulations and their cross-talk in tumorigenesis with a special focus on gliomagenesis.

[Open Biology] Scientists developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

[Stem Cells and Development] Researchers developed a pituitary-like organoid consisting only of gonadotrophs. Despite the lack of success in differentiating gonadotrophs, pituitary-like organoids were differentiated from human-induced pluripotent stem cells.