organoids

[Current Opinion in Neurobiology] Scientists review the most recent advances in modeling Alzheimer's disease in organoids and other engineered 3D cell culture systems.

[Ocular Surface] In serum-free medium, rosiglitazone, a peroxisome proliferator activator receptor-γ agonist, was reported to induce immortalised human meibomian gland epithelia cell differentiation, neutral lipid accumulation and expression of key biomarkers of differentiation.

[Mount SInai] The National Cancer Institute has awarded Mount Sinai researchers $3.15 million in grant funding to assess the potential of a multidisciplinary drug development platform to identify new biological targets for precision-based therapeutics for hepatocellular carcinoma.

[Molecular Biology of the Cell] Scientists utilized a newly generated PyMT mammary tumor mouse model with conditional paxillin ablation in breast tumor epithelial cells, combined with in vitro 3D tumor organoids invasion analysis and 2D calcium switch assays, to assess the roles for paxillin in breast tumor cell invasion.

[Nature Cell Biology] Scientists showed that Cldn18 tumors accurately recapitulated advanced human gastric cancer in terms of disease morphology, aberrant gene expression, molecular markers and sites of distant metastases.

[Cell Stem Cell] Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.