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organoids

Aptamer-Mediated Doxorubicin Delivery Reduces HCC Burden in 3D Organoids Model

[Journal of Controlled Release] Investigators developed a specific aptamer against EpCAM and tested its potential as a drug delivery agent for hepatocellular carcinoma.

SIRT1 Induces the Accumulation of TAMs at Colorectal Cancer Tumor Sites via the CXCR4/CXCL12 Axis

[Cellular Immunology] Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1.

Microbial Regulation of Hexokinase 2 Links Mitochondrial Metabolism and Cell Death in Colitis

[Cell Metabolism] Scientists examined the microbial regulation of hexokinase 2 and its impact on inflammation using mice lacking hexokinase 2 in intestinal epithelial cells.

Genome-Wide Screening in Human Kidney Organoids Identifies Developmental and Disease-Related Aspects of Nephrogenesis

[Cell Stem Cell] A functional dataset allowed improving mesoderm induction by ROCK inhibition, contained monogenetic and complex trait kidney disease genes, confirmed two additional congenital anomalies of the kidney and urinary tract genes, and provided a large candidate list of ciliopathy-related genes.

The Sodium/Glucose Cotransporters as Potential Therapeutic Targets for Cystic Fibrosis Lung Diseases Revealed by Human Lung Organoid Swelling Assay

[Molecular Therapy-Methods & Clinical Development] Scientists derived human proximal lung organoids from patient-derived pluripotent stem cells carrying disease-causing cystic fibrosis transmembrane conductance regulator mutations.

CHK1 Protects Oncogenic KRAS-Expressing Cells from DNA Damage and Is a Target for Pancreatic Cancer Treatment

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

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