organoids

[Clinical and Translational Gastroenterology] Scientists investigated the effect of SSP2518 on guanylyl cyclase C (GCC)-mediated intracellular cyclic guanosine monophosphate levels and on GCC-mediated chloride secretion in intestinal organoids from three patients with distinct activating GCC mutations and from controls.

[Clinical Cancer Research] Prospectively generate patient derived organoids were established from a heterogeneous population of patients with pancreatic ductal adenocarcinoma (PDAC) including both basal and classical PDAC subtypes.

[Cryobiology] Scientists reported the first comprehensive assessment of cryopreservation of endometrial organoids in the domestic mare.

[Current Opinion in Genetics & Development] Investigators discuss how organoid shape is controlled by mechanical cues within the organoid and their interplay with the material properties of the environment.

[Cellular Oncology] The effect of BET inhibition was evaluated using iBET-151, a small-molecule inhibitor of BET proteins, in a large panel of gastric cancer cell lines and xenograft mouse models. The synergistic effect of iBET-151 and paclitaxel was evaluated using an organoid model.

[Journal of Experimental Medicine] Investigators described the discovery of an agonist of the nuclear receptor NR2F1 that specifically activated dormancy programs in malignant cells.