organoids

[Cell Reports] Employing human cerebral organoids, scientists found that chromodomain helicase DNA-binding 8 (CHD8) haploinsufficiency disrupted neurodevelopmental trajectories with an accelerated and delayed generation of, respectively, inhibitory and excitatory neurons that yields, at days 60 and 120, symmetrically opposite expansions in their proportions.

[Journal of Pathology] Investigators determined if patient-derived organoids (PDOs) could be used to personalize poly-chemotherapy regimens by pharmacotyping of treatment-naïve and post neoadjuvant chemotherapy PDAC PDOs.

[Cell Death Discovery] Viral infection is one of the risk factors for Alzheimer's disease (AD), and scientists demonstrated that Zika virus nfection in brain organoids could trigger AD pathological features, including β-amyloid and phosphorylated-Tau expression.

[Nature Communications] Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.

[Scientific Reports] Researchers studied that intra-hepatic bile duct cells could be grown using a human liver organoid platform.

[Nature] Using a non-human primate model of lung injury, together with human organoids and tissue specimens, researchers showed that alveolar type-2 cells in regenerating lungs transiently acquire an alveolar type-0 state from which they can differentiate into either alveolar type-1 cells or respiratory bronchiole-secretory cells.