organoids

[Communications Biology] The authors examined the vertical-mixing effect on brain organoid structures using bioreactors and established inverted brain organoids.

[Nature Communications] Researchers showed that human hepatic organoids, engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD), developed the key features of ARPKD liver pathology in only 21 days.

[Experimental & Molecular Medicine] Scientists focus on adult gastrointestinal organoids and summarize the state-of-the-art protocols for successful transgenesis.

[Nature Neuroscience] Researchers reported the development of a cerebral organoid slice model derived from human induced pluripotent stem cells that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD.

[Cancer Research] In multiple HCC patient-derived organoids and human tumor xenograft models, the drug combination, but neither single drug alone, markedly reduced tumor-initiating cancer cell frequency.

[Journal of Cystic Fibrosis] The authors assessed induction of cystic fibrosis transmembrane conductance regulator (CFTR) function in premature termination codons-containing intestinal organoids using compounds targeting readthrough, nonsense mRNA mediated decay and CFTR protein modulation.