organoids

[Molecular Brain] Scientists utilized no known disease/healthy cerebral organoids (COs) as normal function controls. At 3–4 and 6–10 months post-differentiation, COs with mutations showed no evidence of disease-related pathology.

[Stem Cell Reports] Investigators generated LCA7 retinal organoids harboring a dominant disease-causing mutation in CRX. The LCA7 retinal organoids developed signs of immature and dysfunctional photoreceptor cells, providing a reliable in vitro model to recapitulate LCA7.

[Experimental & Molecular Medicine] The authors describe strategies for establishing primary hepatocyte organoids derived from either adult or fetal liver based on insights from signaling pathways regulating hepatocyte renewal in vivo.

[Experimental & Molecular Medicine] Organoids hold great potential for high-content screening because they recapitulate many aspects of parent tissues and can be derived from patient material.

[Cell Reports] It is urgent to develop disease models to dissect mechanisms regulating SARS-CoV-2 infection. Researchers derived airway organoids from human pluripotent stem cells.

[Environment International] Researchers analysed the suitability of in vitro models for assessing the interaction of micro- and nanoplastics with intestinal cells.