organoids

[Cell Death Discovery] The authors reported that depletion of mitochondrial DNA, pharmacologic inhibition of mitochondrial electron transport chain (mETC) complex I/complex III, or genetic of mETC complex I restricted cancer cell growth and clonogenicity in various preclinical models of liver cancer.

[Experimental & Molecular Medicine] Researchers modeled Fabry disease using human iPSC-derived kidney organoids and the CRISPR–Cas9 genome-editing system.

[Journal of Cancer Research and Clinical Oncology] Scientists summarize recent advancements of 3D tumor vascular model systems which include tissue engineering-based tumor models; vascular organoid models, and organ-on-chips and their importance in replicating the tumor angiogenesis along with the associated challenges to design improved models.

[International Journal of Urology] The authors summarize the development and applications of three-dimensional organoid cultures in urological cancers, mainly focusing on prostate, urinary bladder and kidney cancers, and assess the future prospects of this model.

[Cell Stem Cell] Scientists identified a KRAB-ZFP transcription factor, ZNF558, that was expressed in human but not chimpanzee forebrain neural progenitor cells.

[Cell Communication and Signaling] Researchers review the three methods currently used to establish glioma organoids, and introduced how they play a role in the diagnosis and treatment of glioma.