organoids

[Nature Communications] Researchers developed a comprehensive and highly tuneable ex vivo model of pancreatic ductal adenocarcinoma based on the 3D co-assembly of peptide amphiphiles with custom ECM components.

[Hepatology] Researchers showed that intrahepatic duct cells regenerated upon resumption of Jag/Notch signaling, from multipotent progenitors originating from an Fgf-dependent extrahepatic stem cell niche.

[Oncogene] Scientists investigated the loss of SOX4 in mammary tumor development utilizing organoids derived from a PyMT genetic mouse model of breast cancer.

[Advanced Science] By forced expression of the ectodysplasin-A in human epidermal keratinocytes sweat gland (SwG) culture medium, human epidermal keratinocytes were efficiently converted into SwG cells.

[Cell Death & Disease] By modeling early stages of adenoma initiation researchers observed a reduced apoptotic rate in RAC1B overexpressing tumors, suggesting protection from apoptosis as a mediator of this phenotype.

[Cell Death & Disease] Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.