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organoids

Programmatic Introduction of Parenchymal Cell Types into Blood Vessel Organoids

[Stem Cell Reports] Investigators presented a bottom-up engineering approach to building vascularized human tissue by combining genetic reprogramming with chemically directed organoid differentiation.

Investigating Receptor-Mediated Antibody Transcytosis Using Blood–Brain Barrier Organoid Arrays

[Fluids and Barriers of the CNS] Investigators applied a novel bioengineering approach to generate human blood-brain barrier organoids by the self-assembly of astrocytes, pericytes and brain endothelial cells with unprecedented throughput and reproducibility using micro patterned hydrogels.

Stem/Progenitor Cells in Normal Physiology and Disease of the Pancreas

[Molecular and Cellular Endocrinology] Researchers provide an overview on embryonic and putative adult pancreas progenitors in homeostasis and disease, with special emphasis on in vitro culture systems and scRNA-seq technology as tools to address the progenitor nature of different pancreatic cells.

The Potential of Pancreatic Organoids for Diabetes Research and Therapy

[Islets] Scientists review the attempts over the past decade, to utilize the organoid cell culture principles in order to identify, expand, and differentiate the adult pancreatic stem cells from different compartments of mouse and human pancreata.

FOXC1 Modulates Stem-Like Cell Properties and Chemoresistance through Hedgehog and EMT Signaling in Gastric Adenocarcinoma

[Molecular Therapy] The function of the only gene overexpressed in both chemoresistant tumors and tumor tissue relative to normal gastric epithelia, FOXC1, was examined in gastric adenocarcinoma cells, mouse xenograft models, and patient-derived organoid systems, focusing on cancer stem-like cell phenotypes, metastasis, and chemoresistance

Human Microglia States Are Conserved across Experimental Models and Regulate Neural Stem Cell Responses in Chimeric Organoids

[Cell Stem Cell] Xenotransplantation of human microglia into cerebral organoids allowed us to characterize key transcriptional programs of developing microglia in vitro and revealed that microglia induced transcriptional changes in neural stem cells and decrease interferon signaling response genes.

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