organoids

[Cell Reports] Scientists showed that patient-derived glioma stem cells recruited elevated levels of proteins that ensured the temporal cilium disassembly, leading to suppressed ciliogenesis.

[Communications Biology] The authors described a two-step chemically defined xeno-free method for generating valvular endothelial cell (VEC)-like cells (VELs) from human PSCs (hPSC). When seeded onto the surface of the de-cellularized porcine aortic valve matrix scaffolds, hPSC-derived VELs exhibited superior proliferative and clonogenic potential than the primary VECs and human aortic endothelial cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists performed comparative transcriptomics of 1) isogenic androgen receptor (AR)-positive versus AR-negative prostate cancer cells, 2) AR-positive versus AR-negative prostate cancer tumors, and 3) isogenic JMJD1C-expressing versus JMJD1C-depleted AR-negative prostate cancer cells.

[Oncology Reports] Tumor organoids were developed ex vivo from freshly resected renal cell carcinoma tumors, and their histopathological and molecular characteristics were evaluated using histological staining and whole‑exome sequencing.

[Molecular Brain] The authors generated a human brain organoid model of increased PTEN dosage. They showed that mild PTEN overexpression led to reduced neural precursor proliferation, premature neuronal differentiation, and the formation of significantly smaller brain organoids.

[Aging Cell] Scientists showed that the cGAS-STING pathway was required for the recognition of micronuclei and induction of a senescence-associated secretory phenotype in ataxia-telangiectasia olfactory neurosphere-derived cells and brain organoids.