organoids

[Journal of Molecular Cell Biology] The authors introduced the most recent advances of human embryonic stem cell- or induced pluripotent stem cell-derived organoids to model 3D neuromuscular junctions.

[Cell Reports] Bacteria injected into the organoid lumen entered umbrella-like cells and proliferated to form intracellular bacterial communities -like bodies.

[Biomaterials] Investigators discuss the importance of the extracellular matrix in intestinal, hepatic, and pancreatic organoid culture and how biomaterial-based approaches can be used to probe different ECM properties required for more physiologically and translationally relevant organoid models.

[Journal of Experimental Medicine] Researchers showed that mice deficient in the prostaglandin D2 receptor CRTH2 and mice with CRTH2 deficiency only in nonhematopoietic cells exhibited enhanced worm clearance and intestinal goblet cell hyperplasia following infection with the helminth Nippostrongylus brasiliensis.

[Cellular and Molecular Gastroenterology and Hepatology] Scientists used patient derived organoids to study the epithelial-specific transcriptional and secretome signatures of the ileum during Crohn’s disease with varying phenotypes to screen for disease profiles and potential druggable targets.

[Gastric Cancer] Researchers established oxaliplatin resistant gastric cancer organoids and evaluated their gene expression profile using microarray analysis.