Tag results:
organoids
Organoid News
Anti-Tumor Effect of Trametinib in Bladder Cancer Organoid and the Underlying Mechanism
[Cancer Biology & Therapy] In each bladder cancer organoid strain, epidermal growth factor receptor/ERK signaling was upregulated compared with normal bladder cells.
Neural Cell News
Unraveling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids
[Neuroscientist] With advancement of organoid technology, brain organoids offer a promising tool for unravelling pathophysiologic clues and potential therapeutic options for neuropsychiatric complications of COVID-19.
Mammary Cell News
Small-Molecule Inhibition of Lats Kinases May Promote Yap-Dependent Proliferation in Postmitotic Mammalian Tissues
[Nature Communications] Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.
Organoid News
Using 3D Brain Organoids to Study Prader-Willi Syndrome
[Monash University] Dr. Partha Das of Monash University’s Biomedicine Discovery Institute has been announced as the recipient of the Prader Willi Research Foundation Australia 2020 Prader-Willi Syndrome (PWS) Grant Round. Dr. Das' project will grow and study 3D brain organoids from people with PWS.
Organoid News
Patient-Derived Cancer Organoids for Precision Oncology Treatment
[Journal of Personalized Medicine] Investigators explore the current literature on cancer organoids, highlighting the history of patient-derived organoids (PDOs) development, organoid models of glioma, and potential clinical applications of PDOs.
Intestinal Cell News
LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF Mutant Colorectal Cancer
[Cancer Research] Researchers demonstrated that enteroendocrine progenitor cells were enriched in BRAF mutant colorectal cancer patient tumors, cell lines, and patient-derived organoids.