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organoids

Anti-Tumor Effect of Trametinib in Bladder Cancer Organoid and the Underlying Mechanism

[Cancer Biology & Therapy] In each bladder cancer organoid strain, epidermal growth factor receptor/ERK signaling was upregulated compared with normal bladder cells.

Unraveling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids

[Neuroscientist] With advancement of organoid technology, brain organoids offer a promising tool for unravelling pathophysiologic clues and potential therapeutic options for neuropsychiatric complications of COVID-19.

Small-Molecule Inhibition of Lats Kinases May Promote Yap-Dependent Proliferation in Postmitotic Mammalian Tissues

[Nature Communications] Using a high-throughput phenotypic screen, scientists identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling.

Using 3D Brain Organoids to Study Prader-Willi Syndrome

[Monash University] Dr. Partha Das of Monash University’s Biomedicine Discovery Institute has been announced as the recipient of the Prader Willi Research Foundation Australia 2020 Prader-Willi Syndrome (PWS) Grant Round. Dr. Das' project will grow and study 3D brain organoids from people with PWS.

Patient-Derived Cancer Organoids for Precision Oncology Treatment

[Journal of Personalized Medicine] Investigators explore the current literature on cancer organoids, highlighting the history of patient-derived organoids (PDOs) development, organoid models of glioma, and potential clinical applications of PDOs.

LSD1 and Aberrant DNA Methylation Mediate Persistence of Enteroendocrine Progenitors That Support BRAF Mutant Colorectal Cancer

[Cancer Research] Researchers demonstrated that enteroendocrine progenitor cells were enriched in BRAF mutant colorectal cancer patient tumors, cell lines, and patient-derived organoids.

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