Researchers found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with systemic mastocytosis blocked osteoblast differentiation and mineralization in culture, and when injected into mice diminished the expression of osteoblast markers, and trabecular bone volume and microarchitecture.
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Scientists discuss the normal processes of bone and tooth development, followed by disorders that have effects on both bone and teeth, versus disorders that have effects in one without affecting the other.
[Nature Reviews Endocrinology]
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Scientists found that intra‐articular injection of baicalein ameliorated subchondral bone remodelling. Baicalein impaired angiogenesis of endothelial cells and inhibited proliferation of synovial cells.
[Journal of Cellular and Molecular Medicine]
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Li, B., Chen, K., Qian, N., Huang, P., Hu, F., Ding, T., Xu, X., Zhou, Q., Chen, B., Deng, L., Ye, T., & Guo, L. (n.d.). Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16538 Cite
Investigators describe an unreported function of osteoblasts as a source of testosterone that was especially relevant during androgen‐responsive metastatic prostate cancer invasion into bone.
[Journal of Bone and Mineral Research]
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Moon, H. H., Clines, K. L., O’Day, P. J., Al‐Barghouthi, B. M., Farber, E. A., Farber, C. R., Auchus, R. J., & Clines, G. A. (n.d.). Osteoblasts Generate Testosterone from DHEA and Activate Androgen Signaling in Prostate Cancer Cells. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jbmr.4313 Cite
Scientists developed a novel in vitro collagen matrix system exerting a uniaxially-fixed mechanical boundary condition on which mouse osteoblast-like MC3T3-E1 cells were subcultured, evoking cellular alignment along the uniaxial boundary condition.
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A biomimetic scaffold was developed that allowed rapid and self‐sustained endochondral ossification without initial hypertrophic chondrogenesis.
[Advanced Healthcare Materials]
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Kim, H. D., Hong, X., An, Y.-H., Park, M. J., Kim, D.-G., Greene, A. K., Padwa, B. L., Hwang, N. S., Lin, R.-Z., & Melero‐Martin, J. M. (n.d.). A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. Advanced Healthcare Materials, n/a(n/a), 2100070. https://doi.org/https://doi.org/10.1002/adhm.202100070 Cite
Researchers found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed.
Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.
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Investigators created a high throughput screening and identified SB216763, an inhibitor of glycogen synthase kinase 3, as an inducer of osteoblastic-endothelial transition.
The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.
[Nature Reviews Clinical Oncology]
Using osteoblasts as a model system, scientists observed that prostate cancer cells and their conditioned medium could stimulate and increase mineralisation and osteoblasts’ differentiation.
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