Mastocytosis-Derived Extracellular Vesicles Deliver miR-23a and miR-30a Into Pre-Osteoblasts and Prevent Osteoblastogenesis and Bone Formation

Researchers found that extracellular vesicles released by neoplastic mast cells and present in the serum of patients with systemic mastocytosis blocked osteoblast differentiation and mineralization in culture, and when injected into mice diminished the expression of osteoblast markers, and trabecular bone volume and microarchitecture.
[Nature Communications]
Full Article
Bookmark

No account yet? Register

0
Share

The Role of Biomineralization in Disorders of Skeletal Development and Tooth Formation

Scientists discuss the normal processes of bone and tooth development, followed by disorders that have effects on both bone and teeth, versus disorders that have effects in one without affecting the other.
[Nature Reviews Endocrinology]
Kovacs, C. S., Chaussain, C., Osdoby, P., Brandi, M. L., Clarke, B., & Thakker, R. V. (2021). The role of biomineralization in disorders of skeletal development and tooth formation. Nature Reviews Endocrinology, 1–14. https://doi.org/10.1038/s41574-021-00488-z Cite
Abstract
Bookmark

No account yet? Register

0
Share

Baicalein Alleviates Osteoarthritis by Protecting Subchondral Bone, Inhibiting Angiogenesis and Synovial Proliferation

Scientists found that intra‐articular injection of baicalein ameliorated subchondral bone remodelling. Baicalein impaired angiogenesis of endothelial cells and inhibited proliferation of synovial cells.
[Journal of Cellular and Molecular Medicine]
Li, B., Chen, K., Qian, N., Huang, P., Hu, F., Ding, T., Xu, X., Zhou, Q., Chen, B., Deng, L., Ye, T., & Guo, L. (n.d.). Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16538 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Osteoblasts Generate Testosterone from DHEA and Activate Androgen Signaling in Prostate Cancer Cells

Investigators describe an unreported function of osteoblasts as a source of testosterone that was especially relevant during androgen‐responsive metastatic prostate cancer invasion into bone.
[Journal of Bone and Mineral Research]
Moon, H. H., Clines, K. L., O’Day, P. J., Al‐Barghouthi, B. M., Farber, E. A., Farber, C. R., Auchus, R. J., & Clines, G. A. (n.d.). Osteoblasts Generate Testosterone from DHEA and Activate Androgen Signaling in Prostate Cancer Cells. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jbmr.4313 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Uniaxially Fixed Mechanical Boundary Condition Elicits Cellular Alignment in Collagen Matrix with Induction of Osteogenesis

Scientists developed a novel in vitro collagen matrix system exerting a uniaxially-fixed mechanical boundary condition on which mouse osteoblast-like MC3T3-E1 cells were subcultured, evoking cellular alignment along the uniaxial boundary condition.
[Scientific Reports]
Kim, J., Ishikawa, K., Sunaga, J., & Adachi, T. (2021). Uniaxially fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis. Scientific Reports, 11(1), 9009. https://doi.org/10.1038/s41598-021-88505-z Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification

A biomimetic scaffold was developed that allowed rapid and self‐sustained endochondral ossification without initial hypertrophic chondrogenesis.
[Advanced Healthcare Materials]
Kim, H. D., Hong, X., An, Y.-H., Park, M. J., Kim, D.-G., Greene, A. K., Padwa, B. L., Hwang, N. S., Lin, R.-Z., & Melero‐Martin, J. M. (n.d.). A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. Advanced Healthcare Materials, n/a(n/a), 2100070. https://doi.org/https://doi.org/10.1002/adhm.202100070 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Low Magnitude Vibration Alleviates Age-Related Bone Loss by Inhibiting Cell Senescence of Osteogenic Cells in Naturally Senescent Rats

Researchers found osteogenic cells from aged rats all exhibited senescence changes, with the most pronounced senescence changes in osteocytes. Meanwhile, the proliferative capacity and functional activity of osteogenic cells from aged rats were suppressed.
[Aging]
Aging | Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats - Full Text. (n.d.). Retrieved April 23, 2021, from https://www.aging-us.com/article/202907/text Cite
Full Article
Bookmark

No account yet? Register

0
Share

Ubiquitin Specific Peptidase Usp53 Regulates Osteoblast versus Adipocyte Lineage Commitment

Using ChIP-Seq against NACA in parallel with RNA-sequencing, investigators report the identification of Ubiquitin Specific Peptidase 53 (Usp53) as a target gene of parathyroid hormone-activated nascent polypeptide associated complex and coregulator alpha in osteoblasts.
[Scientific Reports]
Full Article
Bookmark

No account yet? Register

0
Share

Shifting Osteogenesis in Vascular Calcification

Investigators created a high throughput screening and identified SB216763, an inhibitor of glycogen synthase kinase 3, as an inducer of osteoblastic-endothelial transition.
[JCI Insight]
Yao, J., Wu, X., Qiao, X., Zhang, D., Zhang, L., Ma, J. A., Cai, X., Boström, K. I., & Yao, Y. (2021). Shifting osteogenesis in vascular calcification. JCI Insight. https://doi.org/10.1172/jci.insight.143023 Cite
AbstractFull Article
Bookmark

No account yet? Register

0
Share

Novel Approaches to Target the Microenvironment of Bone Metastasis

The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.
[Nature Reviews Clinical Oncology]
Hofbauer, L. C., Bozec, A., Rauner, M., Jakob, F., Perner, S., & Pantel, K. (2021). Novel approaches to target the microenvironment of bone metastasis. Nature Reviews Clinical Oncology, 1–18. https://doi.org/10.1038/s41571-021-00499-9 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Prostate Cancer Cell Extracellular Vesicles Increase Mineralization of Bone Osteoblast Precursor Cells in an In Vitro Model

Using osteoblasts as a model system, scientists observed that prostate cancer cells and their conditioned medium could stimulate and increase mineralisation and osteoblasts’ differentiation.
[Biology]
Lanning, B., Webber, J., Uysal-Onganer, P., Jiang, W. G., Clayton, A., & Dart, D. A. (2021). Prostate Cancer Cell Extracellular Vesicles Increase Mineralisation of Bone Osteoblast Precursor Cells in an In Vitro Model. Biology, 10(4), 318. https://doi.org/10.3390/biology10040318 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share