Inhibition of Axin1 in Osteoblast Precursor Cells Leads to Defects in Postnatal Bone Growth through Suppressing Osteoclast Formation

Osteoclast formation in primary bone marrow derived microphage (BMM) cells was significantly decreased when BMM cells were cultured with conditioned media (CM) collected from osteoblasts derived from Axin1Osx mice compared with BMM cells cultured with CM derived from WT mice.
[Bone Research]
Shu, B., Zhao, Y., Zhao, S., Pan, H., Xie, R., Yi, D., Lu, K., Yang, J., Xue, C., Huang, J., Wang, J., Zhao, D., Xiao, G., Wang, Y., & Chen, D. (2020). Inhibition of Axin1 in osteoblast precursor cells leads to defects in postnatal bone growth through suppressing osteoclast formation. Bone Research, 8(1), 1–8. https://doi.org/10.1038/s41413-020-0104-5 Cite
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Cell Seeding Accelerates the Vascularization of Tissue Engineering Constructs in Hypertensive Mice

The authors investigated the incorporation of cell-seeded poly-L-lactide-co-glycolide scaffolds in hypertensive and nonhypertensive mice. Collagen-coated scaffolds were seeded with osteoblast-like and mesenchymal stem cells.
[Hypertension Research]
Wagner, M. E. H., Kampmann, A., Schumann-Moor, K., Gellrich, N.-C., Tavassol, F., Schmeltekop, F., Rücker, M., Lanzer, M., Gander, T., Essig, H., & Schumann, P. (2020). Cell seeding accelerates the vascularization of tissue engineering constructs in hypertensive mice. Hypertension Research, 1–13. https://doi.org/10.1038/s41440-020-0524-z Cite
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Increased FGF-23 Levels Are Linked to Ineffective Erythropoiesis and Impaired Bone Mineralization in Myelodysplastic Syndromes

Researchers showed that myelodysplastic NUP98‑HOXD13 transgenic mice displayed an abnormally high number of osteoblasts, yet a higher fraction of nonmineralized bone, indicating delayed bone mineralization. This was accompanied by high fibroblast growth factor-23 serum levels, a phosphaturic hormone that inhibits bone mineralization and erythropoiesis.
[JCI Insight]
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Doxycycline Restores the Impaired Osteogenic Commitment of Diabetic-Derived Bone Marrow Mesenchymal Stromal Cells by Increasing the Canonical WNT Signaling

Researchers aimed to address the modulatory capability and associated molecular signaling of a low dosage doxycycline – a semi-synthetic tetracycline, in the functional activity of osteoblastic progenitor cells, established from a translational diabetic experimental model.
[Molecular and Cellular Endocrinology]
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Celastrol Regulates Bone Marrow Mesenchymal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing PGC-1α Signaling

Investigators demonstrated that Celastrol promotes osteoblast differentiation and prevents adipocyte differentiation in bone marrow mesenchymal stem cells in vitro.
[Aging]
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Subarachnoid Transplantation of Human Umbilical Cord Mesenchymal Stem Cell in Rodent Model with Subacute Incomplete Spinal Cord Injury: Preclinical Safety and Efficacy Study

The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
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Functionalisation of a Heat-Derived and Bio-Inert Albumin Hydrogel with Extracellular Matrix by Air Plasma Treatment

Stable and translucent human serum albumin hydrogels were created by controlled thermal gelation and the addition of sodium chloride. The resulting bio-inert hydrogel was then subjected to air plasma treatment which functionalised its surface, enabling the attachment of basement membrane matrix
[Scientific Reports]
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RT-qPCR Analyses on the Osteogenic Differentiation from Human iPS Cells: An Investigation of Reference Genes

Scientists identified the reference genes best suited for experiments that induce osteogenic differentiation from human induced pluripotent stem cells.
[Scientific Reports]
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Canonical Notch Signaling Is Required for Bone Morphogenetic Protein‐Mediated Human Osteoblast Differentiation

Systemic Notch inhibition using diabenzazepine reduced bone morphogenetic protein (BMP)2-induced calvarial bone healing in mice supporting the critical regulatory role of Notch signaling in BMP-induced osteoblastogenesis.
[Stem Cells]
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