osteoblasts

[Cell Reports] Researchers reported a non-invasive all-optical strategy to induce stem cell differentiation in vitro and in vivo that activated individual target stem cells in situ by delivering a transient 100-ms irradiation of a tightly focused femtosecond laser to a submicron cytoplasmic region of primary adipose-derived stem cells.

[Nature Communications] Scientists identified a specific subset of mature osteoblast-derived extracellular vesicles that inhibited bone formation and enhanced osteoclastogenesis.

[iScience] The authors screened out a long non-coding RNA (LncRNA) negatively correlated with osteoblast differentiation, which was therefore named Lnc-differentiation inhibiting factor (DIF). Functional analysis proved that Lnc-DIF inhibited bone formation.

[Bone Research] The authors discuss the mechanical properties, mechanosensitive cell populations, and mechanotransducive signaling pathways of the skeletal system.

[Prostate] Scientists investigated a possible role for protease-activated receptor-2 in regulating the behavior of bone cells exposed to metastatic prostate cancer cells.

[Bone Research] Expression and lineage analysis showed selective expression of discoidin domain receptor 2 (Ddr2) at early stages of bone formation in the resting zone and proliferating chondrocytes and periosteum.