osteoblasts

[Nature Communications] Investigators reported that mechanical force regulated the production of the metabolite asymmetric dimethylarginine via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 expression in osteoblasts.

[PLoS Genetics] The authors generated Rothmund-Thomson syndrome (RTS) patient-derived iPSCs to dissect the pathological signaling leading to RTS patient-associated osteosarcoma.

[Theranostics] Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.

[Journal of Biomaterials Science-Polymer Edition] Researchers probed the use of new biomimetic sulphonated polyether ether ketone-based nanofibrous scaffold to deliver amine functionalized hydroxyapatite nanoparticles loaded resveratrol for its potent functionality in osteogenic differentiation.

[Stem Cell Reviews and Reports] Investigators proposed a 3D environment based on gallic acid grafted-chitosan scaffold and osteoblasts differentiated from human umbilical cord mesenchymal stem cells to recapitulate the main components of hematopoietic stem cells niche.

[ACS Nano] The authors constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance.