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osteoblasts

CD4+ T-cell Activation of Bone Marrow Causes Bone Fragility and Insulin Resistance in Type 2 Diabetes

[Bone] In type 2 diabetes mellitus mice scientists inhibited systemic activation of T cells with a fusion protein between the extracellular domain of Cytotoxic T-Lymphocyte Antigen 4 and the Fc domain of human immunoglobulin G.

miR-29cb2 Promotes Angiogenesis and Osteogenesis by Inhibiting Hif-3α in Bone

[iScience] Scientists showed that miR-29cb2 was a bone-specific miRNA and played critical roles on angiogenesis-osteogenesis coupling during bone remodeling.

Prostate Tumor-Induced Stromal Reprogramming Generates Tenascin C That Promotes Prostate Cancer Metastasis through YAP/TAZ Inhibition

[Oncogene] Investigators showed that endothelial-to-osteoblast (EC-to-OSB) transition led to changes in the tumor microenvironment that increased the metastatic potential of prostate cancer (PCa) cells. They found that conditioned medium from EC-OSB hybrid cells increased the migration and survival of PC3-mm2 and C4-2B4 PCa cells.

Comprehensive Analysis of Human Chorionic Membrane Extracts Regulating Mesenchymal Stem Cells during Osteogenesis

[Cell Proliferation] Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts.

Materials-Driven Fibronectin Assembly on Nanoscale Topography Enhances Mesenchymal Stem Cell Adhesion, Protecting Cells from Bacterial Virulence Factors and Preventing Biofilm Formation

[Biomaterials] The authors used a poly ethyl acrylate polymer coating on titanium nanowires to spontaneously organize fibronectin and to deliver bone morphogenetic protein 2 to enhance MSC adhesion and osteospecific signaling.

3-D Vascularized Breast Cancer Model to Study the Role of Osteoblast in Formation of a Pre-Metastatic Niche

[Scientific Reports] Breast cancer cells preferentially metastasize to bone. To study the bone-tumor paracrine influence, a tri-cellular 3-D vascularized breast cancer tissue model was engineered which comprised MDA-MB231, TNBCs, fibroblasts, and endothelial cells.

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