osteoblasts

[Stem Cell Research & Therapy] In recent years, the application of MSCs in rheumatic diseases has received increasing attention. The authors review the clinical progress in MSC application for the treatment of rheumatic diseases.

[Bioengineered] Researchers demonstrated that exosomes extracted from bone marrow MSCs (BMSC-exo) significantly promoted HFOB1.19 differentiation to osteoblasts, and found that BMSC-exo were enriched with miR-196a and delivered miR-196a to HFOB1.19 cells to inhibit its target Dkk1, which was a negative regulator of Wnt/β-catenin pathway.

[Journal of Experimental Medicine] The authors analyzed exome sequencing data from the UK Biobank, and found clonal hematopoiesis of indeterminate potential to be associated with increased incident osteoporosis diagnoses and decreased bone mineral density.

[Acta Biomaterialia] Researchers examined MSCs/C. acnes interaction and analyzed the subsequent MSCs and bacteria's behaviors. Infected MSCs increased the secretion of prostaglandin E2 and indolamine 2,3 dioxygenase immunomodulatory mediators.

[Journal of Cellular Physiology] Investigators assessed the Mucin 1-mediated effect of hypoxia on the proteomic composition of human osteoblast-derived extracellular matrices (ECM) and characterized their osteogenic and angiogenic potentials in the produced ECMs.

[Bone Research] The authors emphasize the diverse functions of Piezo1 and Piezo2 and related signaling pathways in osteoblast lineage cells and chondrocytes, and summarize key findings about PIEZO gene mutations in human diseases.