TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy–Lysosomal Biogenesis

Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
Tan, A., Prasad, R., & Jho, E. (2021). TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03632-9 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Hypoxia-Inducible Factor-2α Mediates Senescence-Associated Intrinsic Mechanisms of Age-Related Bone Loss

Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

An Integrated Analysis of the Competing Endogenous RNA Network and Co-Expression Network Revealed Seven Hub Long Non-Coding RNAs in Osteoarthritis

Investigators uncovered the hub long non-coding RNAs differentially expressed in osteoarthritis cartilage using an integrated analysis of the competing endogenous RNA network and co-expression network.
[Bone & Joint Research]
Chen, H., & Chen, L. (2020). An integrated analysis of the competing endogenous RNA network and co-expression network revealed seven hub long non-coding RNAs in osteoarthritis. Bone & Joint Research, 9(3), 90–98. https://doi.org/10.1302/2046-3758.93.BJR-2019-0140.R2 Cite
Full Article
Bookmark

No account yet? Register

0
Share

RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of COPD

The effect of cigarette smoke extract on RANKL/RANK expression and that of exogenous RANKL on ubiquitin-proteasome pathway in C2C12 myotubes were investigated in vitro.
[American Journal of Respiratory Cell and Molecular Biology]
Xiong, J., Le, Y., Rao, Y., Zhou, L., Hu, Y., Guo, S., & Sun, Y. (2021). RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of COPD. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2020-0449OC Cite
Abstract
Bookmark

No account yet? Register

0
Share

Two Macrophages, Osteoclasts and Microglia: From Development to Pleiotropy

Investigators discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain, respectively, is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and Alzheimer’s disease.
[Bone Research]
Lee, J.-W., Lee, I.-H., Iimura, T., & Kong, S. W. (2021). Two macrophages, osteoclasts and microglia: from development to pleiotropy. Bone Research, 9(1), 1–10. https://doi.org/10.1038/s41413-020-00134-w Cite
Full Article
Bookmark

No account yet? Register

0
Share

Melatonin Interrupts Osteoclast Functioning and Suppresses Tumor-Secreted RANKL Expression: Implications for Bone Metastases

Investigators observed that melatonin inhibited RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevented cancer-associated osteoclast differentiation.
[Oncogene]
Liu, P.-I., Chang, A.-C., Lai, J.-L., Lin, T.-H., Tsai, C.-H., Chen, P.-C., Jiang, Y.-J., Lin, L.-W., Huang, W.-C., Yang, S.-F., & Tang, C.-H. (2021). Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01613-4 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Adiponectin Signaling in Bone Homeostasis, with Age and in Disease

The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.
[Bone Research]
Lewis, J. W., Edwards, J. R., Naylor, A. J., & McGettrick, H. M. (2021). Adiponectin signalling in bone homeostasis, with age and in disease. Bone Research, 9(1), 1–11. https://doi.org/10.1038/s41413-020-00122-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Breast Cancer Exosomes Contribute to Pre-Metastatic Niche Formation and Promote Bone Metastasis of Tumor Cells

Researchers indicated that breast cancer cell-derived exosomes played an important role in promoting breast cancer bone metastasis, which was associated with the formation of pre-metastatic niche via transferring miR-21 to osteoclasts.
[Theranostics]
Yuan, X., Qian, N., Ling, S., Li, Y., Sun, W., Li, J., Du, R., Zhong, G., Liu, C., Yu, G., Cao, D., Liu, Z., Wang, Y., Qi, Z., Yao, Y., Wang, F., Liu, J., Hao, S., Jin, X., … Li, Y. (2021). Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics, 11(3), 1429–1445. https://doi.org/10.7150/thno.45351 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Kindlin-2 Regulates Skeletal Homeostasis by Modulating PTH1R in Mice

Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.
[Signal Transduction and Targeted Therapy]
Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., Shao, Z., Wang, M., Chen, D., Jin, W., Song, Y., Cao, H., Zhang, G., & Xiao, G. (2020). Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00328-y Cite
Full Article
Bookmark

No account yet? Register

0
Share

RANK Links Thymic Regulatory T Cells to Fetal Loss and Gestational Diabetes in Pregnancy

Investigators showed that the osteoclast differentiation receptor RANK couples female sex hormones to the rewiring of the thymus during pregnancy.
[Nature]
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy | Nature. (n.d.). Retrieved January 5, 2021, from https://www.nature.com/articles/s41586-020-03071-0 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Single-Nucleus RNA-Seq Identifies Transcriptional Heterogeneity in Multinucleated Skeletal Myofibers

Investigators utilized single-nucleus RNA-sequencing to determine the extent of transcriptional diversity within multinucleated skeletal myofibers.
[Nature Communications]
Petrany, M. J., Swoboda, C. O., Sun, C., Chetal, K., Chen, X., Weirauch, M. T., Salomonis, N., & Millay, D. P. (2020). Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers. Nature Communications, 11(1), 6374. https://doi.org/10.1038/s41467-020-20063-w Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share