Novel Population of Human Monocyte and Osteoclast Progenitors from Pluripotent Stem Cells and Peripheral Blood

The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.
[Blood Advances]
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Circulating Cytokines Present in Multiple Myeloma Patients Inhibit the Osteoblastic Differentiation of Adipose Stem Cells

Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.
[Leukemia]
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Osteogenic and Angiogenic Profiles of the Palatal Process of the Maxilla and the Palatal Process of the Palatine Bone

The authors found that the period in which avascular mesenchymal condensation became a vascularized bone structure corresponded to embryonic day 14.5 to embyronic day 16.5 in the hard palate.
[Journal of Anatomy]
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Exosomal miR-19a and IBSP Cooperate to Induce Osteolytic Bone Metastasis of Estrogen Receptor-Positive Breast Cancer

To understand the mechanism of this bone-tropism of ER+ tumor, and to identify liquid biopsy biomarkers for patients with high risk of bone metastasis, the secreted extracellular vesicles and cytokines from bone-tropic breast cancer cells were examined.
[Nature Communications]
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Reelin Depletion Alleviates Multiple Myeloma Bone Disease by Promoting Osteogenesis and Inhibiting Osteolysis

Scientists investigated the regulatory effects of Reelin on multiple myeloma and its underlying pathogenic mechanisms. In vitro studies showed that Reelin depletion regulated osteolysis and osteogenesis balance, cell cycle, invasiveness, and apoptosis in SP2/0 cells.
[Cell Death Discovery]
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Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice

Scientists prepared cartilage from human iPSCs (hiPS-Cart) in a scaffoldless manner and implanted hiPS-Cart into 3.5 mm large defects created in the femurs of immunodeficient mice to examine the repair capacity.
[Tissue Engineering Part A]
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Exosomal Tumor Necrosis Factor-α from Hepatocellular Cancer Cells (Huh-7) Promote Osteoclast Differentiation

Scientists showed that cellular communication of exosomal TNF-α from Huh-7 regulatesdosteoclast differentiation through NF-κB/CTSK/TRAP expressions.
[Journal of Biological Chemistry]
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FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Scientists studied proton radiotherapy (PRT) damage to skin and mesenchymal tissues of muscle and bone and found that flash PRT of the C57BL/6 murine hind leg produced fewer severe toxicities leading to death or requiring euthanasia than standard proton-PRT of the same dose.
[Cancer Research]
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Effector Memory CD4+T Cells in Mesenteric Lymph Nodes Mediate Bone Loss in Food-Allergic Enteropathy Model Mice, Creating IL-4 Dominance

Scientists investigated a non-IgE-mediated food-allergic enteropathy model of ovalbumin (OVA) 23-3 mice expressing OVA-specific T-cell-receptor transgenes.
[Mucosal Immunology]
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STING Suppresses Bone Cancer Pain via Immune and Neuronal Modulation

Investigators reported that agonists of the immune regulator stimulator of interferon genes (STING) confered remarkable protection against cancer pain, bone destruction, and local tumor burden.
[Nature Communications]
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Adenosine Deaminase Modulates Metabolic Remodeling and Orchestrates Joint Destruction in Rheumatoid Arthritis

Scientists presented an integrative analysis of clinical data, cytokines, serum metabolomics in rheumatoid arthritis patients and mechanistic studies on adenosine deaminase-mediated effects on in vitro cell culture models.
[Scientific Reports]
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