Circ_0008542 in Osteoblast Exosomes Promotes Osteoclast-Induced Bone Resorption through m6A Methylation

Scientists showed that exosomes containing circ_0008542 from MC3T3-E1 cells with prolonged tensile stimulation promoted osteoclast differentiation and bone resorption.
[Cell Death & Disease]
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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Apoptotic Mesenchymal Stromal Cells Support Osteoclastogenesis While Inhibiting Multinucleated Giant Cells Formation In Vitro

Scientists focused on the communication from MSCs towards osteoclasts-like cells in vitro. MSCs seeded on a calcium-phosphate biomaterial or undergoing induced apoptosis produced a conditioned media favoring the development of osteoclasts from human CD14+ monocytes.
[Scientific Reports]
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CD13 Is a Critical Regulator of Cell–Cell Fusion in Osteoclastogenesis

Scientists showed that CD13-deficient mice presented a low bone density phenotype with increased numbers of osteoclasts per bone surface, but displayed a normal distribution of osteoclast progenitor populations in the bone marrow and periphery.
[Scientific Reports]
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The KDM4B–CCAR1–MED1 Axis Is a Critical Regulator of Osteoclast Differentiation and Bone Homeostasis

Scientists identified KDM4B as an epigenetic regulator of osteoclast differentiation. Knockdown of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated cells.
[Bone Research]
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Alternative Regulatory Mechanism for the Maintenance of Bone Homeostasis via STAT5-Mediated Regulation of the Differentiation of BMSCs Into Adipocytes

Researchers generated adipocyte-specific Stat5 conditional knockout mice to investigate the role of STAT5 in the adipogenesis of bone marrow mesenchymal stem cells (BMSCs).
[Experimental & Molecular Medicine]
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Tumor- and Osteoclast-Derived NRP2 in Prostate Cancer Bone Metastases

Researchers reported that targeting neuropilin 2 (NRP2) in cancer cells could enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis, implicating NRP2 as a promising therapeutic target.
[Bone Research]
Polavaram, N. S., Dutta, S., Islam, R., Bag, A. K., Roy, S., Poitz, D., Karnes, J., Hofbauer, L. C., Kohli, M., Costello, B. A., Jimenez, R., Batra, S. K., Teply, B. A., Muders, M. H., & Datta, K. (2021). Tumor- and osteoclast-derived NRP2 in prostate cancer bone metastases. Bone Research, 9(1), 1–16. https://doi.org/10.1038/s41413-021-00136-2 Cite
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Efficient Generation of Osteoclasts from Human Induced Pluripotent Stem Cells and Functional Investigations of Lethal CLCN7‐Related Osteopetrosis

Investigators report on a novel, simplified differentiation method for forming functional osteoclasts from hiPSCs.
[Journal of Bone and Mineral Research]
Rössler, U., Hennig, A. F., Stelzer, N., Bose, S., Kopp, J., Søe, K., Cyganek, L., Zifarelli, G., Ali, S., Hagen, M. von der, Strässler, E., Hahn, G., Pusch, M., Stauber, T., Izsvák, Z., Gossen, M., Stachelscheid, H., & Kornak, U. (n.d.). Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis. Journal of Bone and Mineral Research, n/a(n/a). https://doi.org/https://doi.org/10.1002/jbmr.4322 Cite
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A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification

A biomimetic scaffold was developed that allowed rapid and self‐sustained endochondral ossification without initial hypertrophic chondrogenesis.
[Advanced Healthcare Materials]
Kim, H. D., Hong, X., An, Y.-H., Park, M. J., Kim, D.-G., Greene, A. K., Padwa, B. L., Hwang, N. S., Lin, R.-Z., & Melero‐Martin, J. M. (n.d.). A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self-Sustained Endochondral Ossification. Advanced Healthcare Materials, n/a(n/a), 2100070. https://doi.org/https://doi.org/10.1002/adhm.202100070 Cite
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Novel Approaches to Target the Microenvironment of Bone Metastasis

The authors describe the functional roles of the bone microenvironment and its components in the initiation and propagation of skeletal metastases, outline the biology and clinical relevance of circulating tumor cells and disseminated tumor cells, and discuss established and future therapeutic approaches that specifically target defined components of the bone microenvironment to prevent or treat skeletal metastases.
[Nature Reviews Clinical Oncology]
Hofbauer, L. C., Bozec, A., Rauner, M., Jakob, F., Perner, S., & Pantel, K. (2021). Novel approaches to target the microenvironment of bone metastasis. Nature Reviews Clinical Oncology, 1–18. https://doi.org/10.1038/s41571-021-00499-9 Cite
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TFEB Regulates Pluripotency Transcriptional Network in Mouse Embryonic Stem Cells Independent of Autophagy–Lysosomal Biogenesis

Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
Tan, A., Prasad, R., & Jho, E. (2021). TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy–lysosomal biogenesis. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03632-9 Cite
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