Scientists discuss recent findings of miR‐128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.
[Journal of Cellular Physiology]
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Shang, Q., Shen, G., Chen, G., Zhang, Z., Yu, X., Zhao, W., Zhang, P., Chen, H., Tang, K., Yu, F., Tang, J., Liang, D., Jiang, X., & Ren, H. (n.d.). The emerging role of miR-128 in musculoskeletal diseases. Journal of Cellular Physiology, n/a(n/a). https://doi.org/https://doi.org/10.1002/jcp.30179 Cite
Researchers showed that ULK1 deficiency induced an invasive phenotype of breast cancer cells under hypoxia and increases osteolytic bone metastasis.
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Deng, R., Zhang, H.-L., Huang, J.-H., Cai, R.-Z., Wang, Y., Chen, Y.-H., Hu, B.-X., Ye, Z.-P., Li, Z.-L., Mai, J., Huang, Y., Li, X., Peng, X.-D., Feng, G.-K., Li, J.-D., Tang, J., & Zhu, X.-F. (2020). MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. Autophagy, 0(ja), null. https://doi.org/10.1080/15548627.2020.1850609 Cite
Scientists demonstrated that mice with RANKL deficiency in marrow adipogenic lineage precursors MALPs have a drastic increase in trabecular bone mass in long bones and vertebrae starting from one month of age, while their cortical bone appears normal.
[Journal of Clinical Investigation]
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Yu, W., Zhong, L., Yao, L., Wei, Y., Gui, T., Li, Z., Kim, H., Holdreith, N., Jiang, X., Tong, W., Dyment, N. A., Liu, X. S., Yang, S., Choi, Y., Ahn, J., & Qin, L. (2020). Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI140214 Cite
Researchers examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration. Low-magnitude, high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration.
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Yi, X., Wright, L. E., Pagnotti, G. M., Uzer, G., Powell, K. M., Wallace, J. M., Sankar, U., Rubin, C. T., Mohammad, K., Guise, T. A., & Thompson, W. R. (2020). Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity. Bone Research, 8(1), 1–13. https://doi.org/10.1038/s41413-020-00111-3 Cite
Apaired comparison of teeth from the same cat with and without signs of resorption identified 1,732 differentially expressed genes, many of which were characteristic of osteoclast activity and differentiation, in particular MMP9.
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The authors investigated the pro-hematopoietic effects and underlying mechanisms of ziyuglycoside II in cyclophosphamide-induced leukopenia in mice.
[Biomedicine & Pharmacotherapy]
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Researchers investigated the role and mechanisms by which prostate cancer cells induce osteoclastogenesis using cultured monocytic osteoclast precursors.
[Journal of Cellular Biochemistry]
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Researchers investigated the viability and proliferation of osteoblasts, fibroblasts and oral keratinocytes under stratified medium modification and assessed the differentiation of osteoclasts in each co-culture.
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Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes | Scientific Reports. (n.d.). Retrieved October 8, 2020, from https://www.nature.com/articles/s41598-020-73941-0 Cite
Investigators showed that H3.3K36me3 loss on mutant H3.3 altered the deposition of the repressive H3K27me3 mark from intergenic to genic regions, beyond areas of H3.3 deposition. This promoted redistribution of other chromatin marks and aberrant transcription, altering cell fate in mesenchymal progenitors and hindering differentiation.
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Khazaei, S., Jay, N. D., Deshmukh, S., Hendrikse, L. D., Jawhar, W., Chen, C. C., Mikael, L. G., Faury, D., Marchione, D. M., Lanoix, J., Bonneil, E., Ishii, T., Jain, S. U., Rossokhata, K., Sihota, T. S., Eveleigh, R., Lisi, V., Harutyunyan, A. S., Jung, S., … Jabado, N. (2020). H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-0461 Cite
Scientists made an attempt to find out the osteoblastic niche related alterations in the myelodysplastic bone marrow through mainly flowcytometric and fluorescent microscopic studies.
[Molecular and Cellular Biology]
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Osteoblasts, osteoclasts, chondrocytes, and macrophages involved in the bone repair process originate from hematopoietic stem/progenitor cells and mesenchymal stem cells in the bone marrow.
[Inflammation and Regeneration]
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