Scientists proposed a novel mechanism for transcription factor EB (TFEB) governing pluripotency of mESCs by regulating the pluripotency transcriptional network.
[Cell Death & Disease]
Inhibition of senescence-induced upregulation of hypoxia-inducible factor-2α expression during matrix maturation, but not during the proliferation stage of osteoblast differentiation, reversed the age-related decrease in Runx2 and Ocn expression.
[Experimental and Molecular Medicine]
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Investigators uncovered the hub long non-coding RNAs differentially expressed in osteoarthritis cartilage using an integrated analysis of the competing endogenous RNA network and co-expression network.
[Bone & Joint Research]
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Chen, H., & Chen, L. (2020). An integrated analysis of the competing endogenous RNA network and co-expression network revealed seven hub long non-coding RNAs in osteoarthritis. Bone & Joint Research, 9(3), 90–98. https://doi.org/10.1302/2046-3758.93.BJR-2019-0140.R2 Cite
The effect of cigarette smoke extract on RANKL/RANK expression and that of exogenous RANKL on ubiquitin-proteasome pathway in C2C12 myotubes were investigated in vitro.
[American Journal of Respiratory Cell and Molecular Biology]
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Investigators discuss that the Pyk2-mediated actin polymerization pathway in osteoclasts and microglia in bone and brain, respectively, is the horizontal pleiotropic mediator of shared risk factors for osteoporosis and Alzheimer’s disease.
Investigators observed that melatonin inhibited RANKL production in lung and prostate cancer cells by downregulating the p38 MAPK pathway, which in turn prevented cancer-associated osteoclast differentiation.
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Liu, P.-I., Chang, A.-C., Lai, J.-L., Lin, T.-H., Tsai, C.-H., Chen, P.-C., Jiang, Y.-J., Lin, L.-W., Huang, W.-C., Yang, S.-F., & Tang, C.-H. (2021). Melatonin interrupts osteoclast functioning and suppresses tumor-secreted RANKL expression: implications for bone metastases. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01613-4 Cite
The authors explore the current literature on adiponectin in bone, looking in depth at the comparison between human and murine data in health, with age and in disease.
Researchers indicated that breast cancer cell-derived exosomes played an important role in promoting breast cancer bone metastasis, which was associated with the formation of pre-metastatic niche via transferring miR-21 to osteoclasts.
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Yuan, X., Qian, N., Ling, S., Li, Y., Sun, W., Li, J., Du, R., Zhong, G., Liu, C., Yu, G., Cao, D., Liu, Z., Wang, Y., Qi, Z., Yao, Y., Wang, F., Liu, J., Hao, S., Jin, X., … Li, Y. (2021). Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics, 11(3), 1429–1445. https://doi.org/10.7150/thno.45351 Cite
Researchers report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralized the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in murine adult bone.
[Signal Transduction and Targeted Therapy]
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Fu, X., Zhou, B., Yan, Q., Tao, C., Qin, L., Wu, X., Lin, S., Chen, S., Lai, Y., Zou, X., Shao, Z., Wang, M., Chen, D., Jin, W., Song, Y., Cao, H., Zhang, G., & Xiao, G. (2020). Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00328-y Cite
Investigators showed that the osteoclast differentiation receptor RANK couples female sex hormones to the rewiring of the thymus during pregnancy.
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Investigators utilized single-nucleus RNA-sequencing to determine the extent of transcriptional diversity within multinucleated skeletal myofibers.
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Petrany, M. J., Swoboda, C. O., Sun, C., Chetal, K., Chen, X., Weirauch, M. T., Salomonis, N., & Millay, D. P. (2020). Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers. Nature Communications, 11(1), 6374. https://doi.org/10.1038/s41467-020-20063-w Cite