osteoclasts

[Rheumatology] OPG-XL was studied by human induced pluripotent stem cells expressing OPG-XL and two isogenic CRISPR/Cas9-corrected controls in cartilage and bone organoids.

[Bone Research] Scientists identified TNF-α and S100A8/A9 proteins as key regulators that control the inflammatory osteoclast precursor response during chronic inflammation.

[Nature Communications] Scientists identified a specific subset of mature osteoblast-derived extracellular vesicles that inhibited bone formation and enhanced osteoclastogenesis.

[Bone Research] Using genetically modified mice and high-throughput analyses, scientists demonstrated that prolonged hypoxia-inducible factor (HIF)-1α signaling in B cells led to enhanced eceptor activator of nuclear factor kappa-Β production and osteoclast formation.

[Bone Research] The authors discuss the mechanical properties, mechanosensitive cell populations, and mechanotransducive signaling pathways of the skeletal system.

[Prostate] Scientists investigated a possible role for protease-activated receptor-2 in regulating the behavior of bone cells exposed to metastatic prostate cancer cells.