Nanoparticles Functionalized with Stem Cell Secretome and CXCR4-Overexpressing Endothelial Membrane for Targeted Osteoporosis Therapy

Researchers fabricated nanoparticles (NPs) using polylactic-co-glycolic acid loaded with the secretome (Sec) from MSCs to form MSC-Sec NPs.
[Journal of Nanobiotechnology]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Suppression of Breast Cancer-Associated Bone Loss with Osteoblast Proteomes via Hsp90ab1/Moesin-Mediated Inhibition of TGFβ/FN1/CD44 Signaling

Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.
[Theranostics]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Osteoblast/Osteoclast and Immune Cocktail Therapy of an Exosome/Drug Delivery Multifunctional Hydrogel Accelerates Fracture Repair

The authors constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance.
[ACS Nano]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

DCIR and Its Ligand Asialo-Biantennary N-glycan Regulate DC Function and Osteoclastogenesis

Scientists showed that Dcir−/− mice spontaneously developed autoimmune enthesitis and sialadenitis, and also developed metabolic bone abnormalities.
[Journal of Experimental Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractPress Release
Bookmark

No account yet? Register

Share

Loss of Mutual Protection between Human Osteoclasts and Chondrocytes in Damaged Joints Initiates Osteoclast-Mediated Cartilage Degradation by MMPs

Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).
[Scientific Reports]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

A Novel Cytokine Consisting of the p40 and EBI3 Subunits Suppresses Experimental Autoimmune Arthritis via Reciprocal Regulation of Th17 and Treg Cells

The presence of the p40-EBI3 heterodimer was confirmed by ELISA, immunoprecipitation, and western blotting. A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collagen-induced arthritis
[Cellular & Molecular Immunology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

TGF-Beta Pathway Inhibition as the Therapeutic Acceleration of Diabetic Bone Regeneration

Scientists investigated the gene expression profile of bones from type 2 diabetic mice and wild-type mice by comparative microarray analysis before and after placing tibial defects and examined the expression of several osteogenesis- and osteoclastogenesis-related markers by quantitative real-time polymerase chain reaction.
[Journal of Orthopaedic Research]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

An Antibody against Siglec-15 Promotes Bone Formation and Fracture Healing by Increasing TRAP+ Mononuclear Cells and PDGF-BB Secretion

The authors found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.
[Bone Research]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Dnmt3a-Mutated Clonal Hematopoiesis Promotes Osteoporosis

The authors analyzed exome sequencing data from the UK Biobank, and found clonal hematopoiesis of indeterminate potential to be associated with increased incident osteoporosis diagnoses and decreased bone mineral density.
[Journal of Experimental Medicine]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Novel Population of Human Monocyte and Osteoclast Progenitors from Pluripotent Stem Cells and Peripheral Blood

The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.
[Blood Advances]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Circulating Cytokines Present in Multiple Myeloma Patients Inhibit the Osteoblastic Differentiation of Adipose Stem Cells

Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.
[Leukemia]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share