osteoclasts

[Cell Death & Differentiation] USP26 stabilized β-catenin to promote the osteogenic activity of MSCs and impaired the osteoclastic differentiation of bone myelomonocytes by stabilizing inhibitors of NF-κBα.

[Nature Communications] Scientists showed that matrix degradation and chondrocyte phagocytosis were mediated by fatty acid binding protein 5-expressing cells representing septoclasts, which had a mesenchymal origin and were not derived from hematopoietic cells.

[Journal of Nanobiotechnology] Researchers fabricated nanoparticles (NPs) using polylactic-co-glycolic acid loaded with the secretome (Sec) from MSCs to form MSC-Sec NPs.

[Theranostics] Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.

[ACS Nano] The authors constructed a cocktail therapy to simultaneously regulate the osteoblast/osteoclast and M1/M2 macrophage balance.

[Journal of Experimental Medicine] Scientists showed that Dcir−/− mice spontaneously developed autoimmune enthesitis and sialadenitis, and also developed metabolic bone abnormalities.