osteoclasts

[Scientific Reports] Researchers suggested that bone-resident osteoclasts and chondrocytes exerted mutually protective effects on their ‘native’ tissue. However, when osteoclasts contacted non-native cartilage, they caused degradation via matrix metalloproteinases (MMPs).

[Cellular & Molecular Immunology] The presence of the p40-EBI3 heterodimer was confirmed by ELISA, immunoprecipitation, and western blotting. A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collagen-induced arthritis

[Journal of Orthopaedic Research] Scientists investigated the gene expression profile of bones from type 2 diabetic mice and wild-type mice by comparative microarray analysis before and after placing tibial defects and examined the expression of several osteogenesis- and osteoclastogenesis-related markers by quantitative real-time polymerase chain reaction.

[Bone Research] The authors found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.

[Journal of Experimental Medicine] The authors analyzed exome sequencing data from the UK Biobank, and found clonal hematopoiesis of indeterminate potential to be associated with increased incident osteoporosis diagnoses and decreased bone mineral density.

[Blood Advances] The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.