osteoclasts

[Scientific Reports] Scientists showed that CD13-deficient mice presented a low bone density phenotype with increased numbers of osteoclasts per bone surface, but displayed a normal distribution of osteoclast progenitor populations in the bone marrow and periphery.

[Bone Research] Scientists identified KDM4B as an epigenetic regulator of osteoclast differentiation. Knockdown of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated cells.

[Experimental & Molecular Medicine] Researchers generated adipocyte-specific Stat5 conditional knockout mice to investigate the role of STAT5 in the adipogenesis of bone marrow mesenchymal stem cells (BMSCs).

[Bone Research] Researchers reported that targeting neuropilin 2 (NRP2) in cancer cells could enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis, implicating NRP2 as a promising therapeutic target.

[Journal of Bone and Mineral Research] Investigators report on a novel, simplified differentiation method for forming functional osteoclasts from hiPSCs.

[Advanced Healthcare Materials] A biomimetic scaffold was developed that allowed rapid and self‐sustained endochondral ossification without initial hypertrophic chondrogenesis.