Energy Metabolism During Osteogenic Differentiation: The Role of Akt

Investigators tested the effect of osteogenic media containing ascorbate and β-glycerol phosphate, or various osteogenic hormones and growth factors on energy metabolism in long bone- and calvarial bone-derived osteoprogenitors.
[Stem Cells and Development]
Smith, C. O., & Eliseev, R. A. (2020). Energy Metabolism During Osteogenic Differentiation: The Role of Akt. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0141 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Impact of 3D Cell Culture on Bone Regeneration Potential of Mesenchymal Stromal Cells

The authors discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs.
[Stem Cell Research & Therapy]
Bicer, M., Cottrell, G. S., & Widera, D. (2021). Impact of 3D cell culture on bone regeneration potential of mesenchymal stromal cells. Stem Cell Research & Therapy, 12(1), 31. https://doi.org/10.1186/s13287-020-02094-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Mtu1 Defects Are Correlated with Reduced Osteogenic Differentiation

Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful (MSC differentiation. Researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
[Cell Death & Disease]
He, Q., Zhao, Q., Li, Q., Pan, R., Li, X., & Chen, Y. (2021). Mtu1 defects are correlated with reduced osteogenic differentiation. Cell Death & Disease, 12(1), 1–12. https://doi.org/10.1038/s41419-020-03345-5 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Synthesis of Aligned Porous Polyethylene Glycol/Silk Fibroin/Hydroxyapatite Scaffolds for Osteoinduction in Bone Tissue Engineering

The effect of the biophysical microenvironment on rat bone marrow MSC osteogenesis was studied both in vitro and in vivo.
[Stem Cell Research & Therapy]
Yang, Y., Feng, Y., Qu, R., Li, Q., Rong, D., Fan, T., Yang, Y., Sun, B., Bi, Z., Khan, A. U., Deng, T., Dai, J., & Ouyang, J. (2020). Synthesis of aligned porous polyethylene glycol/silk fibroin/hydroxyapatite scaffolds for osteoinduction in bone tissue engineering. Stem Cell Research & Therapy, 11(1), 522. https://doi.org/10.1186/s13287-020-02024-8 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Impact of Tranexamic Acid on Chondrocytes and Osteogenically Differentiated Human Mesenchymal Stromal Cells (hMSCs) In Vitro

Investigators examined the effects of varying exposure times and concentrations of tranexamic acid on proliferation rates, gene expression and differentiation capacity of chondrocytes and human mesenchymal stromal cells, which underwent osteogenic differentiation.
[Journal of Clinical Medicine]
Full Article
Bookmark

No account yet? Register

0
Share

Macrophage-Derived Small Extracellular Vesicles Promote Biomimetic Mineralized Collagen-Mediated Endogenous Bone Regeneration

Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science]
Liu, A., Jin, S., Fu, C., Cui, S., Zhang, T., Zhu, L., Wang, Y., Shen, S. G. F., Jiang, N., & Liu, Y. (2020). Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-00100-6 Cite
Full Article
Bookmark

No account yet? Register

0
Share

YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells

The authors demonstrated that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile phenotype of vascular smooth muscle cells.
[iScience]
AbstractFull ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

Systems Biology Analysis of Osteogenic Differentiation Behavior by Canine Mesenchymal Stem Cells Derived from Bone Marrow and Dental Pulp

The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived MSCs regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression.
[Scientific Reports]
Nantavisai, S., Pisitkun, T., Osathanon, T., Pavasant, P., Kalpravidh, C., Dhitavat, S., Makjaroen, J., & Sawangmake, C. (2020). Systems biology analysis of osteogenic differentiation behavior by canine mesenchymal stem cells derived from bone marrow and dental pulp. Scientific Reports, 10(1), 20703. https://doi.org/10.1038/s41598-020-77656-0 Cite
Full Article
Bookmark

No account yet? Register

0
Share

A Novel Negative Regulatory Mechanism of Smurf2 in BMP/Smad Signaling in Bone

Smurf2 induced the ubiquitination of Smad1/5. Bone morphogenetic protein (BMP)/Smad signaling was enhanced in Smurf2−/− bone marrow stromal cells (BMSCs) stimulated with recombinant human BMP2, and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.
[Bone Research]
Kushioka, J., Kaito, T., Okada, R., Ishiguro, H., Bal, Z., Kodama, J., Chijimatsu, R., Pye, M., Narimatsu, M., Wrana, J. L., Inoue, Y., Ninomiya, H., Yamamoto, S., Saitou, T., Yoshikawa, H., & Imamura, T. (2020). A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Research, 8(1), 1–10. https://doi.org/10.1038/s41413-020-00115-z Cite
Full Article
Bookmark

No account yet? Register

0
Share

Dead Muscle Tissue Promotes Dystrophic Calcification by Lowering Circulating TGF-β1 Level

Scientists demonstrated that suppression of transforming growth factor-beta (TGF-β) signaling promoted dystrophic calcification in vivo, and potentiated osteogenic differentiation of muscle-derived stromal cells in vitro.
[Bone & Joint Research]
Full Article
Bookmark

No account yet? Register

0
Share

Identification of Mesenchymal Stromal Cell Survival Responses to Antimicrobial Silver Ion Concentrations Released from Orthopaedic Implants

The authors determined intramedullary silver release profiles in vivo, which were used to test relevant Ag+ concentrations on MSC function in vitro.
[Scientific Reports]
Souter, P., Vaughan, J., Butcher, K., Dowle, A., Cunningham, J., Dodd, J., Hall, M., Wilson, D., Horner, A., & Genever, P. (2020). Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants. Scientific Reports, 10(1), 18950. https://doi.org/10.1038/s41598-020-76087-1 Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share