Transcriptomic Profiling and Functional Prediction Reveal Aberrant Expression of Circular RNAs during Osteogenic Differentiation in Human Umbilical Cord Mesenchymal Stromal Cells

Investigators analyzed RNA-sequence data to reveal expression profiles of circRNAs during osteogenesis of human umbilical cord MSCs, then elucidated the underlying mechanisms of action.
[Scientific Reports]
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Resveratrol Reverses Osteogenic Decline of Bone Marrow Mesenchymal Stem Cells via Upregulation of YAP Expression in Inflammatory Environment

Investigators found that TNF-α could upregulate inflammatory cytokines, Il-6, Mmp-9, and Il-1β, and establish an inflammatory environment.
[Stem Cells and Development]
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Cyclic Pulsation Stress Promotes Bone Formation of Tissue Engineered Laminae through the F-Actin/YAP-1/β-Catenin Signaling Axis

Researchers found that cerebrospinal fluid pulsation stress—cyclic pulsation stress—could promote the osteogenic and angiogenic abilities of rat MSCs, thereby promoting tissue-engineered laminae’s bone and blood vessel formation.
[NPJ Regenerative Medicine]
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Biofabrication of Allogenic Bone Grafts Using Cellularized Amniotic Scaffolds for Application in Efficient Bone Healing

Using a gradient change of detergents and continuous agitation, scientists developed a unique technique to generate completely cell-free amnion and chorion scaffolds. The absence of cellular components and integrity of biological and mechanical cues within decellularized human amnion and chorion were evaluated and compared with fresh membranes.
[Tissue and Cell]
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Circ_FBLN1 Promotes the Proliferation and Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Regulating Let-7i-5p/FZD4 Axis and Wnt/β-Catenin Pathway

The protein levels of osteogenesis-related genes, let-7i-5p, frizzled class receptor 4, Ki67, Wnt6 and β-catenin were measured by western blot assay. The levels of circ_FBLN1, FBLN1 mRNA and FZD4 mRNA were determined by quantitative real-time PCR assay.
[Journal of Bioenergetics and Biomembranes]
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The Role and Mechanism of Long Non-Coding RNA H19 in Stem Cell Osteogenic Differentiation

Scientists summarize the effect and mechanism of lncRNA H19 on osteogenic differentiation of various stem cells reported in the published literatures. The role and mechanism of H19, H19 expression changes, effect of H19 on cell proliferation in osteogenic differentiation were respectively reviewed.
[Molecular Medicine]
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CGF Membrane Promotes Periodontal Tissue Regeneration Mediated by hUCMSCs through Upregulating TAZ and Osteogenic Differentiation Genes

Scientists explored the role of concentrated growth factor membranes in periodontal tissue regeneration mediated by human umbilical cord MSCs.
[Stem Cells International]
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Long Non-Coding RNA MALAT1 Enhances Angiogenesis during Bone Regeneration by Regulating the miR-494/SP1 Axis

Scientists explored the underlying mechanism of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)-regulated angiogenesis during bone regeneration.
[Laboratory Investigation]
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Degradable RGD-Functionalized 3D-Printed Scaffold Promotes Osteogenesis

The authors proposed to infuse a degradable RGD-functionalized alginate matrix with osteoid-like stiffness, as an artificial ECM, to a rigid 3D-printed hydroxyapatite scaffold for maxillofacial regeneration.
[Journal of Dental Research]
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Engineered Mucoperiosteal Scaffold for Cleft Palate Regeneration towards the Non-immunogenic Transplantation

The authors set up a new natural scaffold deriving from a decellularized porcine mucoperiosteum, engineered by an innovative micro-perforation procedure based on Quantum Molecular Resonance and then subjected to in vitro recellularization with human bone marrow-derived mesenchymal stem cells.
[Scientific Reports]
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Mechanical Load Regulates Bone Growth via Periosteal Osteocrin

Researchers identified a periosteal-osteoblast-derived secretory peptide, Osteocrin, as a mechanotransducer involved in load-induced long bone growth.
[Cell Reports]
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