Investigators tested the effect of osteogenic media containing ascorbate and β-glycerol phosphate, or various osteogenic hormones and growth factors on energy metabolism in long bone- and calvarial bone-derived osteoprogenitors.
[Stem Cells and Development]
The authors discuss current understanding of the effects of different 3D cell culture systems on proliferation, viability and osteogenic differentiation, as well as on the immunomodulatory and anti-inflammatory potential of MSCs.
[Stem Cell Research & Therapy]
Accumulating evidence has revealed that mitochondria dynamics and function regulation is essential for the successful (MSC differentiation. Researchers reported for the first time that Mtu1 defects are correlated with reduced osteogenic differentiation.
[Cell Death & Disease]
The effect of the biophysical microenvironment on rat bone marrow MSC osteogenesis was studied both in vitro and in vivo.
[Stem Cell Research & Therapy]
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Yang, Y., Feng, Y., Qu, R., Li, Q., Rong, D., Fan, T., Yang, Y., Sun, B., Bi, Z., Khan, A. U., Deng, T., Dai, J., & Ouyang, J. (2020). Synthesis of aligned porous polyethylene glycol/silk fibroin/hydroxyapatite scaffolds for osteoinduction in bone tissue engineering. Stem Cell Research & Therapy, 11(1), 522. https://doi.org/10.1186/s13287-020-02024-8 Cite
Investigators examined the effects of varying exposure times and concentrations of tranexamic acid on proliferation rates, gene expression and differentiation capacity of chondrocytes and human mesenchymal stromal cells, which underwent osteogenic differentiation.
[Journal of Clinical Medicine]
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Researchers evaluated the potential role of macrophage-derived small extracellular vesicles (sEVs) in biomimetic mineralized collagen-mediated endogenous bone regeneration in vivo and in vitro. Macrophage-derived sEVs were involved in intrafibrillarly mineralized collagen (IMC)-mediated endogenous bone regeneration in vivo, and IMC-sEVs facilitated MSC osteogenesis through the Smad/1/5/9 pathway.
[International Journal of Oral Science]
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Liu, A., Jin, S., Fu, C., Cui, S., Zhang, T., Zhu, L., Wang, Y., Shen, S. G. F., Jiang, N., & Liu, Y. (2020). Macrophage-derived small extracellular vesicles promote biomimetic mineralized collagen-mediated endogenous bone regeneration. International Journal of Oral Science, 12(1), 1–10. https://doi.org/10.1038/s41368-020-00100-6 Cite
The authors demonstrated that the Hippo pathway effectors YAP and TAZ play a critical role in maintaining the differentiated contractile phenotype of vascular smooth muscle cells.
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The authors illustrated that canine dental pulp stem cells contained superior osteogenicity comparing with canine bone marrow-derived MSCs regarding alkaline phosphatase activity, matrix mineralization, and osteogenic marker expression.
6630899 ZY6BQ2SH items 1 apa default asc 1
Nantavisai, S., Pisitkun, T., Osathanon, T., Pavasant, P., Kalpravidh, C., Dhitavat, S., Makjaroen, J., & Sawangmake, C. (2020). Systems biology analysis of osteogenic differentiation behavior by canine mesenchymal stem cells derived from bone marrow and dental pulp. Scientific Reports, 10(1), 20703. https://doi.org/10.1038/s41598-020-77656-0 Cite
Smurf2 induced the ubiquitination of Smad1/5. Bone morphogenetic protein (BMP)/Smad signaling was enhanced in Smurf2−/− bone marrow stromal cells (BMSCs) stimulated with recombinant human BMP2, and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.
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Kushioka, J., Kaito, T., Okada, R., Ishiguro, H., Bal, Z., Kodama, J., Chijimatsu, R., Pye, M., Narimatsu, M., Wrana, J. L., Inoue, Y., Ninomiya, H., Yamamoto, S., Saitou, T., Yoshikawa, H., & Imamura, T. (2020). A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone. Bone Research, 8(1), 1–10. https://doi.org/10.1038/s41413-020-00115-z Cite
Scientists demonstrated that suppression of transforming growth factor-beta (TGF-β) signaling promoted dystrophic calcification in vivo, and potentiated osteogenic differentiation of muscle-derived stromal cells in vitro.
[Bone & Joint Research]
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The authors determined intramedullary silver release profiles in vivo, which were used to test relevant Ag+ concentrations on MSC function in vitro.
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Souter, P., Vaughan, J., Butcher, K., Dowle, A., Cunningham, J., Dodd, J., Hall, M., Wilson, D., Horner, A., & Genever, P. (2020). Identification of mesenchymal stromal cell survival responses to antimicrobial silver ion concentrations released from orthopaedic implants. Scientific Reports, 10(1), 18950. https://doi.org/10.1038/s41598-020-76087-1 Cite