Circular RNA AFF4 Modulates Osteogenic Differentiation in BM-MSCs by Activating SMAD1/5 Pathway through miR-135a-5p/FNDC5/Irisin Axis

Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
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The Effect of Parathyroid Hormone on Osteogenesis Is Mediated Partly by Osteolectin

Parathyroid hormone (PTH) and sclerostin inhibitor (SOSTi) are bone anabolic agents that are administered to patients with osteoporosis. Scientists tested whether osteolectin mediates the effects of PTH or SOSTi on bone formation.
[Proceedings of the National Academy of Sciences of the United States of America]
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Therapeutic Effect of IL1β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis

IL1β priming Tonsil-derived MSCs had an enhanced osteogenic differentiation and secreted factors that regulate both osteoclastogenesis and osteoblastogenesis.
[Tissue Engineering and Regenerative Medicine]
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Osteogenic Differentiation of Human Mesenchymal Stromal Cells and Fibroblasts Differs Depending on Tissue Origin and Replicative Senescence

To elucidate cell type-specific differences in the osteogenic differentiation potential and replicative senescence, researchers analyzed the impact of BMP and TGF-β signaling in adipose-derived stromal cells, fibroblasts, and dental pulp stromal cells.
[Scientific Reports]
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The N6-Methyladenosine Demethylase ALKBH5 Negatively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells through PRMT6

Researchers showed that conditional knockout of the demethylase Alkbh5 in bone marrow MSCs strengthened bone mass in mice.
[Cell Death & Disease]
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GABARAP Ameliorates IL-1β-Induced Inflammatory Responses and Osteogenic Differentiation in Bone Marrow-Derived Stromal Cells by Activating Autophagy

Researchers investigated whether pro-autophagic γ-aminobutyric acid receptor-associated protein (GABARAP) promoted bone MSCs proliferation and osteogenic differentiation by modulating autophagy in the presence or absence of interleukin-1 beta (IL-1β) in vitro.
[Scientific Reports]
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Notch-Wnt Signal Crosstalk Regulates Proliferation and Differentiation of Osteoprogenitor Cells during Intramembranous Bone Healing

Investigators presented evidence that during intramembranous bone formation osteoprogenitor cell proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling.
[npj Regenerative Medicine]
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Wnt/ß-Catenin-Mediated p53 Suppression Is Indispensable for Osteogenesis of Mesenchymal Progenitor Cells

Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts.
[Cell Death & Disease]
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Spermidine Inhibits Vascular Calcification in Chronic Kidney Disease through Modulation of SIRT1 Signaling Pathway

Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.
[Aging Cell]
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Different Phenotypes and Chondrogenic Responses of Human Menstrual Blood and Bone Marrow Mesenchymal Stem Cells to Activin A and TGF-β3

Investigators evaluatedchondrogenic differentiation potential of menstrual blood-derived mesenchymal stem/stromal cells (MSCs) and bone marrow MSCs stimulated with transforming growth factor β (TGF-β3) and activin A.
[Stem Cell Research & Therapy]
Uzieliene, I., Bagdonas, E., Hoshi, K., Sakamoto, T., Hikita, A., Tachtamisevaite, Z., Rakauskiene, G., Kvederas, G., Mobasheri, A., & Bernotiene, E. (2021). Different phenotypes and chondrogenic responses of human menstrual blood and bone marrow mesenchymal stem cells to activin A and TGF-β3. Stem Cell Research & Therapy, 12(1), 251. https://doi.org/10.1186/s13287-021-02286-w Cite
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Histone Modifications Centric-Regulation in Osteogenic Differentiation

Investigators improve the understanding of the role of histone modifications in osteogenic differentiation and describe its potential as a therapeutic target for osteogenic differentiation-related diseases.
[Cell Death Discovery]
Li, K., Han, J., & Wang, Z. (2021). Histone modifications centric-regulation in osteogenic differentiation. Cell Death Discovery, 7(1), 1–8. https://doi.org/10.1038/s41420-021-00472-6 Cite
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