Disruption of Hematopoiesis Attenuates the Osteogenic Differentiation Capacity of Bone Marrow Stromal Cells

The authors investigated the effect of hematopoietic cells on MSCs using various methods, including flow cytometry, adipogenic and osteogenic differentiation analysis, quantitative PCR, western bloting, and microCT analysis.
[Stem Cell Research & Therapy]
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NAP1L2 Drives Mesenchymal Stem Cell Senescence and Suppresses Osteogenic Differentiation

The authors screened the gene expression profiles of human bone marrow MSCs (BMSCs) from young and old donors and identified that elevation of the nucleosome assembly protein 1-like 2 (NAP1L2) expression was correlated with BMSC senescence and impaired osteogenesis.
[Aging Cell]
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MicroRNA-149 Suppresses Osteogenic Differentiation of Mesenchymal Stem Cells via Inhibition of AKT1-Dependent Twist1 Phosphorylation

Scientists elucidated the role of miR-149 in osteogenic differentiation of MSCs and the underlying mechanism.
[Cell Death Discovery]
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Patient-Derived iPSCs Link Elevated Mitochondrial Respiratory Complex I Function to Osteosarcoma in Rothmund-Thomson Syndrome

The authors generated Rothmund-Thomson syndrome (RTS) patient-derived iPSCs to dissect the pathological signaling leading to RTS patient-associated osteosarcoma.
[PLoS Genetics]
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The ERα/KDM6B Regulatory Axis Modulates Osteogenic Differentiation in Human Mesenchymal Stem Cells

Researchers found that estrogen significantly induced the expression of lysine-specific demethylase 6B (KDM6B) and that KDM6B depletion by shRNAs led to a significant reduction in the osteogenic potential of dental mesenchymal stromal cells.
[Bone Research]
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Diesel Exhaust Particles Impair Therapeutic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells against Experimental Colitis through ROS/ERK/cFos Signaling Pathway

Researchers reported the effects of diesel exhaust particles exposure on the properties of human Wharton’s jelly-derived mesenchymal stem cells, including stemness, regeneration, and immunomodulation.
[International Journal of Stem Cells]
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Design and Development of Biomimetic Electrospun Sulphonated Polyether Ether Ketone Nanofibrous Scaffold for Bone Tissue Regeneration Applications: In Vitro and In Vivo Study

Researchers probed the use of new biomimetic sulphonated polyether ether ketone-based nanofibrous scaffold to deliver amine functionalized hydroxyapatite nanoparticles loaded resveratrol for its potent functionality in osteogenic differentiation.
[Journal of Biomaterials Science-Polymer Edition]
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Rho-GEF Trio Regulates Osteosarcoma Progression and Osteogenic Differentiation through Rac1 and RhoA

Investigators found that Trio was highly expressed in osteosarcoma than normal tissues and promoted the proliferation, migration, and invasion of osteosarcoma cells.
[Cell Death & Disease]
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Human Platelet Lysate (hPL) Alters the Lineage Commitment and Paracrine Functions of Human Mesenchymal Stem Cells via Mitochondrial Metabolism

Scientists showed that MSCs cultured in hPL displayed a reduced cell size and cell spreading, but an improved proliferation and osteogenic capability compared with cells maintained in fetal bovine serum.
[Applied Materials Today]
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Bone Morphogenetic Protein 9 Enhances Osteogenic and Angiogenic Responses of Human Amniotic Mesenchymal Stem Cells Cocultured with Umbilical Vein Endothelial Cells through the PI3K/AKT/M-TOR Signaling Pathway

The authors investigated the effects of bone morphogenetic protein 9 on osteogenesis and angiogenesis of human amniotic mesenchymal stem cells (hAMSCs) cocultured with human umbilical vein endothelial cells (HUVECs) and determined the possible underlying molecular mechanism.
[Aging]
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Comprehensive Analysis of Human Chorionic Membrane Extracts Regulating Mesenchymal Stem Cells during Osteogenesis

Researchers showed the in vitro and in vivo bone-forming ability of chorionic membrane extract (CME) using human osteoblasts and bone defect animal models, suggesting that CME greatly enhanced osteogenesis by providing an osteoconductive environment for the osteogenesis of osteoblasts.
[Cell Proliferation]
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