osteogenic differentiation

[Molecular Therapy-Nucleic Acids] Investigators analyzed the circRNA expression profile of five samples of bone marrow MSCs in osteonecrosis of the femoral head (ONFH) and five samples of control by using circular RNA microarray assays.

[DNA and Cell Biology] Researchers analyzed the contribution of hydroxyapatite scaffold to the osteogenic differentiation of human placenta-derived mesenchymal stem cells from the perspective of miRNA differential expression.

[Cell and Tissue Research] Methyltransferase-like 3 (METTL3) facilitated osteogenic differentiation of bone marrow MSCs via the LINC00657/miR-144-3p/BMPR1B axis.

[Journal of Tissue Engineering] The authors developed four different 2D cell-based decellularized matrices and a 3D decellularized human trabecular-bone scaffold to evaluate bone marrow-MSC behavior.

[Scientific Reports] Evaluations using human MSCs showed that pure polylactic acid (PLA) scaffolds exerted an osteoconductive effect, whereas PLA/hydroxyapatite scaffolds efficiently induced osteogenic differentiation of MSCs even in the absence of any classical osteogenic stimuli.

[Bone Research] Expression and lineage analysis showed selective expression of discoidin domain receptor 2 (Ddr2) at early stages of bone formation in the resting zone and proliferating chondrocytes and periosteum.